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Micrometastasis of Epithelial Tumors: Signum Mortis for the Patient or the Achilles’ Heel of Cancer?

  • G. Riethmüller
  • K. Pantel
  • I. Funke
  • G. Schlimok

Abstract

Remembering Walter Brendel’s long-standing enthusiasm for tumor immunology, we have chosen a topic dealing with our most recent approach to identifying and defining micrometastatic cancer cells in bone marrow. When we met Walter for the first time in the mid-1960s, he was fascinated, as were many of us, by the idea that tumors might follow the same rules of acceptance and rejection as allografts. At that time we were not fully aware of the common history of tumor immunology and transplantation immunology, which had cross-fertilized each other already for some time. We are fortunate that Avrion Mitchison is with us here as witness of the early days when Gorer in the search of tumor rejection antigens discovered the major histocompatibility complex of mice.

Keywords

Metastatic Cell Disseminate Tumor Cell Tumor Immunology Individual Tumor Cell Bone Marrow Micrometastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Boone T, Van Pel A, De Plaen E, Van den Eynde B, Hainant P (1989) Genes coding for TUM- transplantation antigens. A model for TSTA? In: Melchers F et al. (eds) Progress in Immunology, Vol 7. Springer, Berlin Heidelberg New York, pp 1063–1070Google Scholar
  2. 2.
    Moll R, Franke WW, Schiller DL, Geiger B, Krepler R (1982) The catalogue of human cytokeratins: pattern of expression in normal epithelia, tumors and cultured cells. Cell 31: 11–24PubMedCrossRefGoogle Scholar
  3. 3.
    Debus E, Weber K, Osborn M (1982) Monoclonal cytokeratin antibodies that distinguish simple from stratified squamous epithelia: characterization on human tissues. Embo J 1: 1641–1647PubMedGoogle Scholar
  4. 4.
    Schlimok G, Funke I, Holzmann B, Göttlinger H, Schmidt G, Häuser H, Swierkot S, Warnecke HH, Schneider B, Koprowski H, Riethmüller G (1987) Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labelling with anti 17–1A-monoclonal antibodies. Proc Natl Acad Sci USA 84: 8672–8676PubMedCrossRefGoogle Scholar
  5. 5.
    Riethmüller G, Schlimok G, Lehmann JM, Stade BG, Funke I, Bock B, Schweiberer B, Johnson JP (1989) Immunological analysis of micrometastases and the metastatic phenotype of human tumors. In: Melchers F et al. (eds) Progress in Immunology, Vol. 7. Springer, Berlin Heidelberg New York, pp 1079–1086Google Scholar
  6. 6.
    Schlimok G, Funke I, Bock B, Schweiberer B, Witte J, Riethmüller G (1990) Epithelial tumor cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterization and prognostic significance. J Clin Oncol 8: 831–837PubMedGoogle Scholar
  7. 7.
    Schlimok G, Funke I, Strobel F, Witte J, Riethmüller G (1990) Comparative analysis of monoclonal antibodies for the detection of epithelial micrometastatic tumor cells in bone marrow and its clinical application to gastric cancer. (in press)Google Scholar
  8. 8.
    Weiss L, Grundmann E, Torhorst J et al. (1986) Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 150: 195–203PubMedCrossRefGoogle Scholar
  9. 9.
    Funke I, Schlimok G, Bock B, Schweiberer B, Riethmüller G (1989) Micrometastasis: characterization and tumorigenicity of disseminated tumor cells in human bone marrow. In: Osborne M, Weber K (eds.) Current communications in molecular biology. Cold Spring Harbor Laboratory, New York, pp 214–244Google Scholar
  10. 10.
    Delsol G, Gatter KC, Stein H, Erber WN, Pulford KAF, Zinne K, Mason DY (1984) Human lymphoid cells express epithelial membrane antigen. Lancet 2: 1124–1129PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • G. Riethmüller
  • K. Pantel
  • I. Funke
  • G. Schlimok

There are no affiliations available

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