Nucleotide Sequence Determination As a Diagnostic Tool

  • A. C. Syvänen
  • H. Söderlund


Identification of nucleic acids is a valuable tool in diagnostics due to the high specificity of this approach. Nucleic acid hybridization identifies and quantifies specific genes. Hybridization with oligonucleotide probes or nucleotide sequencing can be used to detect genetic variations even as small as point mutations. Widespread diagnostic use of nucleic acid analyses has been limited by the very small amount of analyte present in most applications.


Acute Myeloid Leukemia Human Papilloma Virus Affinity Matrix Human Papilloma Virus Type Nucleotide Sequence Variation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. C. Syvänen
  • H. Söderlund
    • 1
  1. 1.BiotechnologyOrion PharmaceuticaHelsinkiFinland

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