The Significance of IgG Peptides and Sugars for the Development of Autoimmunity in Rheumatoid Arthritis
Rheumatoid factors, a useful diagnostic aid for rheumatoid arthritis, have come a long way since their discovery in 1937 by Erik Waaler (Waaler 1940). Exciting new information is revealing that rheumatoid factors are generated from a limited set of germ line genes. Most detailed studies on rheumatoid factor utilize immunoglobulins from disease in which there is a malignant proliferation of rheumatoid factor producing cells as in chronic lymphocytic leukemia or where there is a benign proliferation of a lymphoid clone. Increasingly, it appears that a limited number of clones are used in rheumatoid arthritis as well, but that they may be somatically mutated to give a limited degree of oligoclonality (Shlomchik et al. 1987).
KeywordsChronic Lymphocytic Leukemia Rheumatoid Factor Complementarity Determine Region Germ Line Gene Light Chain Variable Region
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