The Significance of IgG Peptides and Sugars for the Development of Autoimmunity in Rheumatoid Arthritis
Rheumatoid factors, a useful diagnostic aid for rheumatoid arthritis, have come a long way since their discovery in 1937 by Erik Waaler (Waaler 1940). Exciting new information is revealing that rheumatoid factors are generated from a limited set of germ line genes. Most detailed studies on rheumatoid factor utilize immunoglobulins from disease in which there is a malignant proliferation of rheumatoid factor producing cells as in chronic lymphocytic leukemia or where there is a benign proliferation of a lymphoid clone. Increasingly, it appears that a limited number of clones are used in rheumatoid arthritis as well, but that they may be somatically mutated to give a limited degree of oligoclonality (Shlomchik et al. 1987).
KeywordsSugar Arthritis Leukemia Lysine Arginine
Unable to display preview. Download preview PDF.
- Andrew DW, Capra JD (1981) Complete amino acid sequence of variable domains from two monoclonal human anti-gamma-globulins of the Wa cross idiotypic group. Suggestion that the J segments are involved in structural correlates of the idiotype. Proc Natl Acad Sci USA 783: 799Google Scholar
- Goni F, Chen PP, Pons-Estel B, Carson DA, Frangione B (1985) Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgMk with anti-y-globulin activity. J Immuno1 135:4073Google Scholar
- Thompson KM, Randen I, Natvig JB, Mageed RM, Jefferis R, Carson DA, Tighe H, Forre 0 (1990) Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue incidence of cross-reactive idiotypes and expression of Vu and V subgroups. Eur J Immunol 20: 863Google Scholar