The Significance of IgG Peptides and Sugars for the Development of Autoimmunity in Rheumatoid Arthritis

  • F. C. Hay
  • A. J. Soltys
  • G. Tribbic
  • H. M. Geysen

Abstract

Rheumatoid factors, a useful diagnostic aid for rheumatoid arthritis, have come a long way since their discovery in 1937 by Erik Waaler (Waaler 1940). Exciting new information is revealing that rheumatoid factors are generated from a limited set of germ line genes. Most detailed studies on rheumatoid factor utilize immunoglobulins from disease in which there is a malignant proliferation of rheumatoid factor producing cells as in chronic lymphocytic leukemia or where there is a benign proliferation of a lymphoid clone. Increasingly, it appears that a limited number of clones are used in rheumatoid arthritis as well, but that they may be somatically mutated to give a limited degree of oligoclonality (Shlomchik et al. 1987).

Keywords

Sugar Arthritis Leukemia Lysine Arginine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • F. C. Hay
    • 1
  • A. J. Soltys
    • 1
  • G. Tribbic
    • 2
  • H. M. Geysen
    • 2
  1. 1.Division of ImmunologySt George’s Hospital Medical SchoolLondonUK
  2. 2.Coselco Mimotopes PtyMelbourneAustralia

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