Cancer and Leukemia Group B Studies in Relapsed AML
In the past 20 years, substantial progress has been made in the treatment of acute myeloid leukemia (AML), previously a uniformly fatal diseae. Initial treatment usually consists of a combination of cytosine arabinoside (Ara-C) and daunorubicin, and complete remission (CR) is achieved in approximately 65 % of patients with somewhat higher response rates in younger patients. Once CR is achieved, further chemotherapy is necessary to pro?duce long term disease free survival. How?ever, the majority of patients will relapse; despite the use of these two active drugs as postremission therapy in schedules that have included a 30-fold increase in the dose of Ara-C, there has been, at best, only a modest improvement in survival. Thus, despite 15 year of use of the combination of daunorubicin and Ara-C, the fraction of patients cured with chemotherapy remains in the range 20%–25 % [1–5]. Substantial improvement in long-term disease-free survival has been elusive.
KeywordsToxicity Leukemia Cyclophosphamide Sine Benzoquinone
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