Protein Binding of Teniposide In Vitro and in Children with Acute Lymphoblastic Leukemia

  • J. D. Borsi
  • W. P. Petros
  • J. H. Rodman
  • W. E. Evans
  • R. Koos
  • D. Schuler
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)

Abstract

Teniposide (VM-26) is an epipodophyllotoxin anticancer drug, widely used as a single agent or in combination for the treatment of children with different malignancies (acute lymphoblastic leukemia, lymphomas, neuroblastoma). It is a phase-specific cytotoxic agent inducing premitotic block in the cell cycle by stabilizing the DNA-topoisomerase II complex. The dose-limiting toxicity of the drug is myelosuppression.

Keywords

Methotrexate Bilirubin Neuroblastoma Etoposide Cytosine 

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References

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    Sinkule JA, Stewart CF, Crom WR; Melton ET, Dahl GV et al: Teniposide (VM-26) disposition in children with leukemia. Cancer Res 1984 44: 1235–1237PubMedGoogle Scholar
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    Huang J: Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis. J Pharm Sci 1983. 72: 1368–1369PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. D. Borsi
    • 1
  • W. P. Petros
    • 2
  • J. H. Rodman
    • 2
  • W. E. Evans
    • 2
  • R. Koos
    • 2
  • D. Schuler
    • 1
  1. 1.Second Department of PediatricsSemmelweis Medical SchoolBudapestHungary
  2. 2.St. Jude Children’s Research HospitalMemphisUSA

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