Sensitivity of Childhood Acute Lymphoblastic Leukemia Cells to Prednisolone and Dexamethasone Assessed by the MTT Assay

  • G. J. L. Kaspers
  • R. Pieters
  • C. H. Van Zantwijk
  • F. C. De Waal
  • E. R. Van Wering
  • A. J. P. Veerman
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)


Glucocorticoids like predniso(lo)ne and dexamethasone are well known for their antileukemic activity, especially in acute lymphoblastic leukemia (ALL). Several groups have investigated the sensitivity of malignant lymphoid cells to glucocorticoids (GCs) and possibilities to predict this sensitivity. Special attention was given to the correlation between GC receptor numbers and sensitivity to these drugs, with conflicting results [1–4]. The clinical response to an initial prednisone (PRD) monotherapy was shown to have prognostic value in childhood ALL, firstly in small patient-groups [3, 5], later in the large BFM-ALL 83 study [6]. Differences in GC sensitivity might be important to consider in the design of an optimal treatment for each individual. In vitro sensitivity testing is an attractive method to investigate these differences.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Glucocorticoid Receptor Disodium Phosphate Antileukemic Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • G. J. L. Kaspers
    • 1
  • R. Pieters
    • 1
  • C. H. Van Zantwijk
    • 1
  • F. C. De Waal
    • 1
    • 2
  • E. R. Van Wering
    • 2
  • A. J. P. Veerman
    • 1
    • 2
  1. 1.Department of PediatricsFree University HospitalAmsterdamThe Netherlands
  2. 2.Dutch Childhood Leukemia Study GroupThe HagueThe Netherlands

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