Sensitivity of Childhood Acute Lymphoblastic Leukemia Cells to Prednisolone and Dexamethasone Assessed by the MTT Assay
Glucocorticoids like predniso(lo)ne and dexamethasone are well known for their antileukemic activity, especially in acute lymphoblastic leukemia (ALL). Several groups have investigated the sensitivity of malignant lymphoid cells to glucocorticoids (GCs) and possibilities to predict this sensitivity. Special attention was given to the correlation between GC receptor numbers and sensitivity to these drugs, with conflicting results [1–4]. The clinical response to an initial prednisone (PRD) monotherapy was shown to have prognostic value in childhood ALL, firstly in small patient-groups [3, 5], later in the large BFM-ALL 83 study . Differences in GC sensitivity might be important to consider in the design of an optimal treatment for each individual. In vitro sensitivity testing is an attractive method to investigate these differences.
KeywordsAcute Myeloid Leukemia Acute Lymphoblastic Leukemia Glucocorticoid Receptor Disodium Phosphate Antileukemic Activity
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