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Therapy of Relapsed Acute Myeloid Leukemia Using Targeted Plasma Concentrations of Cytosine Arabinoside and Etoposide

  • J. MirroJr.
  • W. Crom
  • J. Belt
  • M. Schell
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)

Abstract

While the outcome for children with acute lymphocytic leukemia (ALL) has improved as a result of increased dose intensity, the same improvement has not occurred in acute myeloid leukemia (AML). Although approximately 85% of children with AML achieve a complete remission (CR), the majority ultimately relapse and die of their disease [1–5]. Although bone marrow transplant (BMT) offers better disease control, patient selection and the timing of transplantation remains controversial [6–8]. Furthermore, because of the risk of early death and the development of graftversus-host disease, clinical trials have not clearly demonstrated that BMT is the treatment of choice for AML in the first CR [9].

Keywords

Acute Myeloid Leukemia Clin Oncol Cytosine Arabinoside Acute Nonlymphocytic Leukemia Relapse Acute Myeloid Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. MirroJr.
    • 1
  • W. Crom
    • 1
  • J. Belt
    • 1
  • M. Schell
    • 1
  1. 1.Departments of Hematology-Oncology, Pharmacokinetics, Biochemical Pharmacology, and BiostatisticsSt. Jude Children’s Research HospitalMemphisUSA

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