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Dose-Dependent Cellular and Systemic Pharmacokinetics of Cytosine Arabinoside

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

Abstract

The proper selection of dose for any desired therapeutic effect must consider the drug’s systemic and cellular pharmacokinetics. Pharmacokinetics, the measurement of drug concentration over time, is essential to the attainment of a desired pharmacodynamic effect. Correlation of cellular pharmacokinetics with systemic pharmacokinetics offers opportunities for optimal dosage and schedule selection so as to achieve the optimal therapeutic index.

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Author information

Authors and Affiliations

  1. Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, 300 S. Hawthorne Road, Winston-Salem, NC, 27103, USA

    R. L. Capizzi & J. C. White

Authors
  1. R. L. Capizzi
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  2. J. C. White
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of MĂĽnster, Albert-Schweitzer-StraĂźe 33, D-4400, MĂĽnster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Capizzi, R.L., White, J.C. (1992). Dose-Dependent Cellular and Systemic Pharmacokinetics of Cytosine Arabinoside. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_42

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

  • eBook Packages: Springer Book Archive

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