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Dose-Dependent Cellular and Systemic Pharmacokinetics of Cytosine Arabinoside

  • R. L. Capizzi
  • J. C. White
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)

Abstract

The proper selection of dose for any desired therapeutic effect must consider the drug’s systemic and cellular pharmacokinetics. Pharmacokinetics, the measurement of drug concentration over time, is essential to the attainment of a desired pharmacodynamic effect. Correlation of cellular pharmacokinetics with systemic pharmacokinetics offers opportunities for optimal dosage and schedule selection so as to achieve the optimal therapeutic index.

Keywords

Acute Myeloid Leukemia Acute Myeloid Leukemia Cell Cytosine Arabinoside Leukemic Blast Nucleoside Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • R. L. Capizzi
    • 1
  • J. C. White
    • 1
  1. 1.Bowman Gray School of MedicineComprehensive Cancer Center of Wake Forest UniversityWinston-SalemUSA

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