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Acute Leukemias pp 214–221Cite as

Chronic Myelogenous Leukemia in Blastic Phase: A Model of Heterogeneity and Resistance in Acute Leukemia

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Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

Abstract

The heterogeneity and resistance of chronic myelogenous leukemia in blastic phase (CML-BP) are attributed to: (1) the involvement of the earliest progenitor cell by the disease ptocess and (2) the acquisition of multiple mutational events during the evolution from the chronic to the blastic phase.

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Author information

Authors and Affiliations

  1. Departments of Hematology, MD Anderson Cancer Center, 1515 Holcombe Blrd., Houston, Texas, 77030, USA

    H. M. Kantarjian (Scholar of the Leukemia Society of America), S. O’Brien, E. Estey, W. Plunkett, W. Zhang, M. J. Keating & A. Deisseroth

  2. Clinical Immunology and Biological Therapy, MD Anderson Cancer Center, 1515 Holcombe Blrd., Houston, Texas, 77030, USA

    M. Talpaz & M. Wetzler

Authors
  1. H. M. Kantarjian
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  2. M. Talpaz
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  3. M. Wetzler
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  4. S. O’Brien
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  5. E. Estey
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  6. W. Plunkett
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  7. W. Zhang
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  8. M. J. Keating
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  9. A. Deisseroth
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Kantarjian, H.M. et al. (1992). Chronic Myelogenous Leukemia in Blastic Phase: A Model of Heterogeneity and Resistance in Acute Leukemia. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_32

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

  • eBook Packages: Springer Book Archive

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