Abstract
Interleukin 1 (IL-1) plays a major role in the response to infection, in inflammation, and in every immunological challenge. Over the past 10 years a variety of additional activities, especially of purified IL-1 on various target cells in vitro, has been reported [1]. As shown by Shirakawa et al. [2], IL-1 enhances also natural killer (NK) cell cytotoxic effect and proliferation. Expression of IL-2 receptors on NK cell surface can be regulated by IL-1 [3]. [4] Although IL-1 acts directly on many immunocompetent cells its role in malignant diseases has not yet been extensively explored [5]. We have previously reported apparent deficiency of IL-1 production by mononuclear cells of children with acute lymphoblastic leukemia (ALL) during the whole period of cytostatic therapy [6].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fibbe E, Schaafsma MR, Falkenburg FJ, Willmze R (1989) The biological activities of interleukin 1. Blut 59: 177
Shirakawa F, Tanaka Y, Eto S, Suzuki H, Yodo Y, Yamashita U (1986) Effect of interleukin 1 on the expression of interleukin 2 receptor (TAC antigen) on human natural killer cells and natural killer-like cell line (YT cells). J Immunol 137: 551
Kataoka Y, Todo S, Morioka Y, Sugie K, Nakamura Y, Yodoi J, Imashuku S (1990) Impaired natural killer activity and expression of interleukin 2 receptor antigen in familial erythophagocytic lymphohistiocytosis. Cancer 65: 1937
Peppoloni S, Bossu P, Boraschi D, Tagliabue A (1989) A short synthetic peptide fragment of human interleukin 113 increases both human and murine natural killer activity. Nat Immun Cell Growth Regul 8: 10–19
Herman JA, Kew MC, Rabson AR (1984) Defective interleukin-1 production by monocytes from patients with malignant diseases: interferon increasas IL-1 production. Cancer Immunol Immunother 16: 182–185
Chybicka A, Boguslawska-Jaworska J (1990) Interleukin 1 production in childhood acute lymphoblastic leukemia during chemo-and radiotherapy according to BFM (BerlinFrankfurt-Munster) protocol. In: Büchner T et al. Acute leukemias II. Berlin Heidelberg New York 33: 72 (Hematology and blood transfusion)
Frydecka I (1985) Natural killer cell activity during the course of disease in patients with Hodgkin’s disease. Cancer 56: 2799
Pross HF, Maroun JA (1984) The standardisation of NK cell assays for use in studies of biological response modifiers. J Immunol Methods 68: 235
Zimecki M, Wieczorek Z (1987) IL-1 decreases the level of thymocytes forming rosettes with autologous erythrocytes, a new method of determination of I1–1 activity. Arch Immunol Ther Exp (Warsz) 355: 371
Migliorati G, Cannarile L, D’Adamio L, Herberman RB, Riccardi C (1987) Interleukin 1 auguments the interleukin 2 dependent generation of natural killer cells from bone marrow precursor. Nat Immun Cell Growth Regul 6: 306
Pross HF, Baines M (1987) Alterations in natural killer cell activity in tumor-bearing hosts. In: Herberman RB, et al. (eds) Immune responses to metastases. CRC Press, Boca Raton, p 57
Lange A, Flad HD, Jack A, Ulmer AJ (1986) Effect of human recombinant interleukin 2 on natural killing of low density percoll fraction cells. Immunol Lett 12: 243–250
Douer D, Shaked N, Ramot B (1987) Normal natural killer activity in Hodgkin’s disease patients in remission. Clin exp Immunol 69: 660–667
Mehta BA, Satam MN, Advani H, Nadkarin JJ (1989) In vitro modulation of natural killer cell activity in non-Hodgkin’s lymphoma patients after therapy. Cancer Immunol Immunother 28: 148–152
Tanaka Y (1981) Natural killer NK activity in children with acute lymphoblastic leukemia. Hiroshima J Med Sci 30: 127
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Chybicka, A., Boguslawska-Jaworska, J., Budzyński, W., Radzikowski, C., Jaworski, W. (1992). Interleukin-1 Production by Mononuclear Cells and Natural Killer Cell Activity in Children with Acute Lymphoblastic Leukemia. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-76591-9_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53949-0
Online ISBN: 978-3-642-76591-9
eBook Packages: Springer Book Archive