Interleukin-1 Production by Mononuclear Cells and Natural Killer Cell Activity in Children with Acute Lymphoblastic Leukemia
Interleukin 1 (IL-1) plays a major role in the response to infection, in inflammation, and in every immunological challenge. Over the past 10 years a variety of additional activities, especially of purified IL-1 on various target cells in vitro, has been reported . As shown by Shirakawa et al. , IL-1 enhances also natural killer (NK) cell cytotoxic effect and proliferation. Expression of IL-2 receptors on NK cell surface can be regulated by IL-1 .  Although IL-1 acts directly on many immunocompetent cells its role in malignant diseases has not yet been extensively explored . We have previously reported apparent deficiency of IL-1 production by mononuclear cells of children with acute lymphoblastic leukemia (ALL) during the whole period of cytostatic therapy .
KeywordsHepatitis Lymphoma Leukemia Interferon Prostaglandin
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