Abstract
A body of in vitro evidence suggests that use of granulocyte-macrophage colony-stimulating factor (GM-CSF) might increase the in vivo sensitivity of leukemic myeloblasts to daunorubicin-cytosine arabinoside (ara-C) chemotherapy [1–4]. If so, administration of GM-CSF prior to and during administration of daunorubicin/ara-C might overcome the resistance to therapy that is characteristic of acute myeloid leukemia (AML). This resistance is most obvious in patients with abnormalities of chromosomes 5, 7, (−5, −7, 5q-, 7q-) who frequently fail even to enter initial complete remission (CR), but it is also a major problem in patients with other aneuploidies (except INV(16), t (15; 17), or t (8; 21)), or with a normal karyotype or insufficient metaphases for analysis [5].While the majority of these patients enter CR, their remissions rarely last more than 2 years.
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References
Cannistra SA, Groshek P, Griffin JD (1989) Granulocyte-macrophage colony-stimulating factor enhances the cytotoxic effects of cytosine arabinoside in acute myeloblastic leukemia and in the myeloid blast crisis of chronic myeloid leukemia. Leukemia 3: 328–334
Hiddemann W, Kiehl M, Schleyer E, Woermann B, Zuehlsdorf M, Buechner T (1989) Stimulating effect of GM-CSF and IL-3 on the metabolism and cytotoxic activity of cytosine arabinoside in leukemia blasts from patients with acute myeloid leukemia. Blood 74 (Suppl 1): 230a
Santini V, Noater K, Delwel R, Loewenberg B (1990) Susceptibility of acute myeloid leukemia cells from clinically resistant and sensi tive patient to daunomycin: assessment in vitro after stimulation with colony stimulating factors. Leuk Res 14: 377–380
Tafuri A, Andreeff M (1990) Kinetic rationale for cytokine-induced recruitment of myelo blastic leukemia followed by cycle-specific chemotherapy in vitro. Leukemia 4: 826–835
Keating M, Cork A, Broach Y, Smith T, Walters R, McCredie K, Trujillo J, Freireich E (1987) Toward a clinically relevant cytogenetic classification of acute myelogenous leukemia. Leuk Res: 119–133
Cassileth PA, Harrington DP, Hines JD, Oken MM, Maza JJ, McGlave P, O’Connell MJ (1988) Maintenance chemotherapy prolongs remission duration in adult acute none lymphocytic leukemia. J Clin Oncol 6: 583–587
Keating M, Smith T, Kantarjian H, Cork A, Walters R, Trujillo J, McCredie K, Gehan E, Freireich E (1988) Cytogenetic pattern in acute myelogenous leukemia: a major repro ducible determinant of outcome. Leukemia 2: 403–412
Estey E, Smith T, Keating M, McCredie K, Gehan E, Freireich E (1989) Prediction of survival during induction therapy in patients with newly diagnosed acute myelogenous leukemia. Leukemia 3: 257–263
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© 1992 Springer-Verlag Berlin Heidelberg
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Estey, E. et al. (1992). Use of Granulocyte-Macrophage Colony-Stimulating Factor Prior to Chemotherapy of Newly Diagnosed AML. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_15
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DOI: https://doi.org/10.1007/978-3-642-76591-9_15
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