Role of Mitoxantrone, High-Dose Cytosine Arabinoside, and Recombinant Human GM-CSF in Aggressive Non-Hodgkin’s Lymphoma
The activity of mitoxantrone in patients with pretreated aggressive non-Hodgkin’s lymphoma (NHL) has been demonstrated in several phase II studies [1–3]. In a previous phase II trial, the present authors investigated the efficacy of mitoxantrone combined with cytarabine (Ara-C) in conventional doses for patients with refractory disease , but the response rates did not seem to have improved as compared with mitoxantrone alone. Encouraging results have been reported on the use of high-dose Ara-C alone in relapsed NHL [5–7]. In patients with refractory acute leukemia, the combination of high-dose Ara-C and mitoxantrone has been shown to be active [8, 9]. We have initiated a series of studies with this combination for refractory NHL.
KeywordsClin Oncol Autologous Stem Cell Transplantation High Dose Cytosine Arabinoside Refractory Acute Leukemia Diffuse Histiocytic Lymphoma
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