Role of Mitoxantrone, High-Dose Cytosine Arabinoside, and Recombinant Human GM-CSF in Aggressive Non-Hodgkin’s Lymphoma

  • A. D. Ho
  • F. Del Valle
  • R. Haas
  • M. Engelhard
  • W. Hiddemann
  • H. Rückle
  • G. Schlimok
  • E. Thiel
  • R. Andreesen
  • W. Fiedler
  • W. Hunstein
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)


The activity of mitoxantrone in patients with pretreated aggressive non-Hodgkin’s lymphoma (NHL) has been demonstrated in several phase II studies [1–3]. In a previous phase II trial, the present authors investigated the efficacy of mitoxantrone combined with cytarabine (Ara-C) in conventional doses for patients with refractory disease [4], but the response rates did not seem to have improved as compared with mitoxantrone alone. Encouraging results have been reported on the use of high-dose Ara-C alone in relapsed NHL [5–7]. In patients with refractory acute leukemia, the combination of high-dose Ara-C and mitoxantrone has been shown to be active [8, 9]. We have initiated a series of studies with this combination for refractory NHL.


Clin Oncol Autologous Stem Cell Transplantation High Dose Cytosine Arabinoside Refractory Acute Leukemia Diffuse Histiocytic Lymphoma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • A. D. Ho
    • 1
    • 2
  • F. Del Valle
    • 3
  • R. Haas
    • 1
  • M. Engelhard
    • 4
  • W. Hiddemann
    • 5
  • H. Rückle
    • 6
  • G. Schlimok
    • 7
  • E. Thiel
    • 8
  • R. Andreesen
    • 9
  • W. Fiedler
    • 10
  • W. Hunstein
    • 1
  1. 1.Department of Internal MedicineUniversity of HeidelbergHeidelbergGermany
  2. 2.Northeastern Ontario Regional Cancer CentreSudburyCanada
  3. 3.Städtische Kliniken OldenburgOldenburgGermany
  4. 4.Department of Internal MedicineUniversity of EssenEssenGermany
  5. 5.Department of Internal MedicineUniversity of MünsterMünsterGermany
  6. 6.Department of Internal MedicineUniversity of WürzburgWürzburgGermany
  7. 7.Zentralklinikum AugsburgAugsburgGermany
  8. 8.Department of Internal Medicine, Klinikum SteglitzUniversity of BerlinBerlinGermany
  9. 9.Department of Internal MedicineUniversity of FreiburgFreiburgGermany
  10. 10.Department of Oncology and HematologyUniversity of HamburgHamburgGermany

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