Scrapie Strain Variation and Its Implications
Strain variation in scrapie was first recognised about 30 years ago, when experimental sheep scrapie was transmitted to and serially passaged in goats. Two separate passage lines were maintained which produced strikingly different clinical signs in unselected goats from the same herd, either a “drowsy” or a “scratching” syndrome (Pattison and Millson 1961). This difference between the two isolates remained constant on repeated goat-to-goat passage. Since then, overwhelming evidence for scrapie strain variation has accumulated, mainly from the long-term studies conducted in Edinburgh by Dickinson and coworkers (including ourselves), who have serially passaged scrapie from a wide range of natural and experimental sources in inbred mice (Dickinson 1976). About 20 strains of scrapie have been identified so far in mice, each with its own distinct and repeatable set of disease characteristics.
KeywordsShort Incubation Period Mouse Genotype Scrapie Agent Scrapie Strain Scrapie Infectivity
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- Bruce ME, Dickinson AG (1979) Biological stability of different classes of scrapie agent. In: Prusiner SJ, Hadlow WJ (eds) Slow transmissible diseases of the nervous system, vol 2. Academic, New York, pp 71–86Google Scholar
- Dickinson AG (1976) Scrapie in sheep and goats. In: Kimberlin RH (ed) Slow virus diseases of animals and man. North-Holland, Amsterdam, pp 209–241Google Scholar
- Dickinson AG, Fraser H (1977) Scrapie pathogenesis in inbred mice: an assessment of host control and response involving many strains of agent. In: Ter Meulen V, Katz M (eds) Slow virus infections of the central nervous system. Springer, Berlin Heidelberg New York, pp 3–14Google Scholar
- Dickinson AG, Outram GW (1983) Operational limitations in the characterisation of the infective units of scrapie. In: Court LA, Cathala F (eds) Virus nonconventionnels et affections du systeme nerveux central, Masson, Paris, pp 3–16Google Scholar
- Dickinson AG, Bruce ME, Outram GW, Kimberlin RH (1984) Scrapie strain differences: the implications of stability and mutation. In: Tateishi J (ed) Proceedings of workshop on slow transmissible diseases. Japanese Ministry of Health and Welfare, Tokyo, pp 105–118Google Scholar
- Fraser H (1976) The pathology of natural and experimental scrapie. In: Kimberlin RH (ed) Slow virus diseases of animals and man. North-Holland, Amsterdam, pp 267–305Google Scholar
- Kimberlin RH (1979) Early events in the pathogenesis of scrapie in mice: biological and biochemical studies. In: Prusiner SB, Hadlow WJ (eds) Slow transmissible diseases of the nervous system, vol 2. Academic, New York, pp 33–54Google Scholar
- McBride PA, Bruce ME, Fraser H (1988) Immunostaining of scrapie cerebral amyloid plaques with-antisera raised to scrapie-associated fibrils (SAF). Neuropathol Appl Neurobiori4: 325–336Google Scholar
- Outram GW (1976) The pathogenesis of scrapie in mice. In: Kimberlin RH (ed) Slow virus diseases of animals and man. North-Holland, Amsterdam, pp 325–357Google Scholar
- Somerville RA, Ritchie LA (1986) Are scrapie associated fibrils a pathological product of infection? In: Court LA, Dormont D, Brown P, Kingsbury DT (eds) Unconventional virus diseases of the central nervous system. Commissariat à l’Énergie Atomique, Fontenay-aux-Roses, pp 521–535Google Scholar