Atrial Thrombosis, Rat, Mouse, and Hamster

  • William W. Carlton
  • Jeffery A. Engelhardt
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Rodents with atrial thrombosis can be recognized at necropsy. The left atrium is swollen, firm, and mottled white and red. Other associated lesions in hamsters include pulmonary edema and pleural effusion. Mice with atrial thrombosis have a dilated left atrium that is firm with irregular gray areas. The wall of the thrombosed atrium is stretched and thin (Fry et al. 1965; Frith et al. 1983). In cut section, a single thrombus or multiple thrombi fill most of the atrial lumen and may project into the mitral opening. The site and extent of attachment of the thrombus to the atrial wall varies from animal to animal. The exposed thrombus is gray to tan and may be laminated. Recently formed thrombi are firm and inelastic and gray-red (Wilens and Sproul 1938). Rupture of the distended atrium with hemorrhage into the pericardial and pleural cavities occurs, but is rare.


Left Atrium Erucic Acid Syrian Hamster Atrial Wall Testosterone Propionate 
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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • William W. Carlton
  • Jeffery A. Engelhardt

There are no affiliations available

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