Chondro-Osseous Lesions Induced by Adriamycin, Rabbit

  • David M. Young
  • David J. Prieur
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Young rabbits treated with multiple intravenous injections of Adriamycin (doxorubicin hydrochloride), a broad-spectrum antitumor antibiotic, over a period of 3–5 months develop an unthrifty appearance associated with decreased gains in body weight. A dose schedule of 0.7 mg/kg (7.7 mg/m2 body surface area) three times per week produces lesions consistently over a period of 13–18 weeks at cumulative doses of 27.3 mg/kg (300 mg/m2) - 37.8 mg/kg (416 mg/m2), respectively. Roentgenographs of long bones reveal thin cortices and narrowed diaphyseal shafts (Figs. 363,364). Epiphyseal areas have a generlized radiolucent appearance with lytic patterns varying from motheaten (cancellous type) to cystic. Multiple lucent holes of varying sizes are scattered throughout the epiphysis intermixed with prominent trabecular densities. Metaphyseal zones frequently contain radiodense coarse trabeculation representative of tightly packed cancellous bone (Fig. 364).

Keywords

Phosphorus Osteoporosis Cortisol Flare Doxorubicin 

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References

  1. Adinoff AD, Hollister JR (1983) Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med 309: 265–268PubMedCrossRefGoogle Scholar
  2. Cournot-Witmer G, Bourdeau A, Lieberherr M, Thil CL, Plachot JJ, Enault G, Bourdon R, Balsan S (1987) Bone modeling in gallium nitrate-treated rats. Calcif Tissue Int 40: 270–275PubMedCrossRefGoogle Scholar
  3. Cruess RL (1986) Osteonecrosis of bone: current con-cepts as to etiology and pathogenesis. Clin Orthop 208: 30–39PubMedGoogle Scholar
  4. El-Sharkawi AM, Morgan WD, Cobbold S, Jaib MBM, Evans CJ, Somervaille LJ, Chettle DR, Scott MC (1986) Unexpected mobilisation of lead during cis- platin chemotherapy. Lancet 2: 249–250PubMedCrossRefGoogle Scholar
  5. Feitelberg S, Epstein S, Ismail F, d’Amanda C (1987) Deranged bone mineral metabolism in chronic alcoholism. Metabolism 36: 322–326PubMedCrossRefGoogle Scholar
  6. Ihde DC, DeVita VT (1975) Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination therapy. Cancer 36: 1585–1588PubMedCrossRefGoogle Scholar
  7. Karim AC, Eddy EL (1984) A light and electron microscopic study of osteodentin formation in the rat incisor after adriamycin administration. Am J Anat 169: 207–219PubMedCrossRefGoogle Scholar
  8. Mettler FP, Young DM, Ward JM (1977) Adriamycin- induced cardiotoxicity (cardiomyopathy and congestive heart failure) in rats. Cancer Res 37: 2705–2713PubMedGoogle Scholar
  9. Pauli RM, Feldman PF (1986) Major limb malformations following intrauterine exposure to ethanol: two additional cases and literature review. Teratology 33: 273–280PubMedCrossRefGoogle Scholar
  10. Pierce RO Jr, Pierce RO II, Pierce GW (1985) The effect of alcohol on the skeletal system. Orthop Rev 14: 83–87Google Scholar
  11. Rossleigh MA, Smith J, Straus DJ, Engel IA (1986) Osteonecrosis in patients with malignant lymphoma. A review of 31 classes. Cancer 58: 1112–1116PubMedCrossRefGoogle Scholar
  12. Saville PD (1975) Alcohol related skeletal disorders. Ann NY Acad Sci 252: 287–291PubMedCrossRefGoogle Scholar
  13. Scher HI, Curley T, Geller N, Dershaw D, Chan E, Nisselbaum J, Alcock N, Hollander P, Yagoda A (1987) Gallium nitrate in prostatic cancer: evaluation of antitumor activity and effects on bone turnover. Cancer Treat Rep 71: 887–893PubMedGoogle Scholar
  14. Turner RT, Greene VS, Bell NH (1987) Demonstration that ethanol inhibits bone matrix synthesis and mineralization in the rat. J Bone Miner Res 2: 61–66PubMedCrossRefGoogle Scholar
  15. Warrell RP Jr, Bockman RS, Coonley CJ, Isaaes M, Staszewski H (1984) Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia. J Clin Invest 73: 1487–1490PubMedCrossRefGoogle Scholar
  16. Young DM (1975) Pathologic effects of adriamycin (NSC-123127) in experimental systems. Cancer Chem Rep 6: 159–175Google Scholar
  17. Young DM, Fioravanti JL, Oslon HM, Prieur DJ (1975) Chemical and morphologic alterations of rabbit bone induced by Adriamycin. Calcif Tissue Res 18: 47–63PubMedCrossRefGoogle Scholar
  18. Kirk A, Raghupathy P, Stevens MM, Cowell CT, Menser MA, Bergin M, Tink A, Vines RH, Silink M (1987) Growth failure and growth-hormone deficiency after treatment for acute lymphoblastic leukaemia. Lancet 1: 190–193PubMedCrossRefGoogle Scholar
  19. Marymont JV, Kaufman EE (1986) Osteonecrosis of bone associated with combination chemotherapy without corticosteroids. Clin Orthop 204: 150–153PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • David M. Young
  • David J. Prieur

There are no affiliations available

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