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Lathyrogen-Induced Lesions of Bone, Rat

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Cardiovascular and Musculoskeletal Systems

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

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Abstract

Intraperitoneal injection of 300 mg aminoace- tonitrile per kilogram body weight in to pregnant rats on the 15th day post-coitum results in grossly visible effects on the fetuses. Distortion of the front paws and extension of lower limbs is grossly evident in the fetus (Fig. 357). This is described by Pratt and King (1972), Steffek et al. (1972), and Barrow and Steffek (1974) as an effect of p-aminoproprionitrile (BAPN) and by Schmidt et al. (1980) and Wendler et al. (1980) after the administration of aminoacetonitrile (A AN).

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Authors
  1. Wolfgang Schmidt
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Editors and Affiliations

  1. Emeritus, Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street, N.W., 20036, Washington D.C., USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  2. Medizinische Hochschule Honnover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, W-3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Schmidt, W. (1991). Lathyrogen-Induced Lesions of Bone, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_42

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  • DOI: https://doi.org/10.1007/978-3-642-76533-9_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76535-3

  • Online ISBN: 978-3-642-76533-9

  • eBook Packages: Springer Book Archive

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