Bone Lesions, X-Linked Hypophosphatemic (Hyp) Mouse

  • Ralph A. MeyerJr.
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


X-linked hypophosphatemia is a genetically dominant, metabolic bone disease that occurs in both humans and mice (Rasmussen and Anast 1983). The X-linked hypophosphatemic (Hyp) mouse is characterized by dwarfism, rickets, osteomalacia, and low plasma phosphate (Eicher et al. 1976; Meyer et al. 1979). There is a reduced renal tubular reabsorption of phosphate (Eicher et al. 1976) that accounts for the hypophosphatemia and is a major cause of the bone disease. There are abnormalities in the bone growth of the craniofacial region (Iorio et al. 1980). In Addition, synostosis of the cranial and facial sutures has been found in the skull (Roy et al 1981) (Figs. 341, 342).


Hypophosphatemic Rickets Facial Suture Femoral Mineral Progressive Ankylosis Resistant Rickets 
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© Springer-Verlag Berlin Heidelberg 1991

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  • Ralph A. MeyerJr.

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