Osteosarcoma, Spontanous and Radiation-Induced, Mouse

  • Arne Luz
  • Wolfgang Gössner
  • A. Beatrice Murray
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Osteosarcomas appear as reddish-gray nodules, largely of dense, hard consistency, affixed to a bone. The preferential location in long bones is the metaphysis, but they can develop in the diaphysis. The most frequent location in our NMRI mice is the vertebral column (Table 14). These tumors can be detected by the resulting paralysis of the legs. There is no significant difference in the skeletal distribution of spontaneous and radionuclide-induced osteosarcomas; however, when short-lived radionuclides are administered to grown animals the proportion of tumors in the vertebral column becomes somewhat higher.


Vertebral Column NMRI Mouse Spindle Cell Sarcoma Vascular Type Osteoblastic Osteosarcoma 
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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Arne Luz
  • Wolfgang Gössner
  • A. Beatrice Murray

There are no affiliations available

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