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Osteosarcoma, Spontanous and Radiation-Induced, Mouse

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Cardiovascular and Musculoskeletal Systems

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Osteosarcomas appear as reddish-gray nodules, largely of dense, hard consistency, affixed to a bone. The preferential location in long bones is the metaphysis, but they can develop in the diaphysis. The most frequent location in our NMRI mice is the vertebral column (Table 14). These tumors can be detected by the resulting paralysis of the legs. There is no significant difference in the skeletal distribution of spontaneous and radionuclide-induced osteosarcomas; however, when short-lived radionuclides are administered to grown animals the proportion of tumors in the vertebral column becomes somewhat higher.

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Authors
  1. Arne Luz
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  2. Wolfgang Gössner
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  3. A. Beatrice Murray
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Editor information

Editors and Affiliations

  1. Emeritus, Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street, N.W., 20036, Washington D.C., USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  2. Medizinische Hochschule Honnover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, W-3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Luz, A., Gössner, W., Murray, A.B. (1991). Osteosarcoma, Spontanous and Radiation-Induced, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_31

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  • DOI: https://doi.org/10.1007/978-3-642-76533-9_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76535-3

  • Online ISBN: 978-3-642-76533-9

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