Abstract
Large osteomas are seen at autopsy as yellowish-white hard nodules which project from the involved bone. The X-ray reveals a circum-scribed mass of dense bone with a sharp outline (Figs. 210, 211). Characteristic locations are the tabula interna of the skull, the diaphyses of the long bones, and the os ilium. The vertebral column and other bones may also be involved. Symmetric involvement of paired bones may occur in cases with numerous tumors per animal.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Behnisch W (1988) Molekulare Klonierung und Charakterisierung der murinen osteotropen Leuk- ämieviren RFB und OS-5. University of Munich ( Wissenschaftliche Forschungsbeiträge: Biologie/Bio- chemie/Chemie, vol 17 )
Charles RT, Turusov VS (1974) Bone tumours in CF-1 mice. Lab Anim 8: 137–144
Dahlin DC, Unni KK (1986) Bone tumors: general aspects and data on 8542 cases, 4th edn. Thomas, Springfield
Erfle V, Schmidt J, Strauss GP, Hehlmann R, Luz A (1986) Activation and biological properties of en-dogenous retroviruses in radiation osteosarcoman- genesis. Leuk Res 10: 905–913
Finkel MP, Reilly CA Jr, Biskis BO, Greco IL (1973) Bone tumor viruses. In: Price CHG, Ross FGM (eds) Bone-certain aspects of neoplasia. Butterworth, London, pp 353–364
Furth J (1946) Prolongation of life with prevention of leukemia by thymectomy in mice. J Gerontol 1: 46–54
Huvos AG (1979) Bone tumors: diagnosis, treatment prognosis. Saunders, Philadelphia Jacobson SA ( 1971 ) Comparative pathology of the tumors of bone. Thomas, Springfield
Jubb KVF, Kennedy PC, Palmer N (1985) Pathology of domestic animals, vol 1, 3rd edn. Academic, Orlando
Leib-Mösch C, Schmidt J, Etzerodt M, Pedersen FS, Hehlmann R, Erfle V (1986) Oncogenic retrovirus from spontaneous murine osteomas. II. Molecular cloning and genomic characterization. Virology 150: 96–105
Lowy DR, Rands E, Chattopadhyay SK, Garon SK, Hager GL (1980) Molecular cloning of infectious integrated murine leukemia virus DNA from infected mouse cells. Proc Natl Acad Sci USA 77: 614–618
Marquart KH (1979) Pleomorphic C-type virus particles in bone tissue of strain 101 mice and (C3H x 101)F1 hybrids. Calcif Tissue Int 28: 259–262
Rudali G, Coezy E, Gourdon AC (1968) Hyperostoses intracraniennes chez des souris apres administration d’un anticonceptionnel. Rev Fr Etud Clin Biol 13: 195–199
Schajowicz F (1981) Tumors and tumor like lesions of bone and joints. Springer, Berlin Heidelberg New York
Schajowicz F, Ackerman LV, Sissons HA, Sobin LH, Torloni H (1972) Histological typing of bone tumours. WHO, Geneva (International histological classification of tumours, no 6 )
Schmidt J, Erfle V, Pedersen FS, Rohmer H, Schetters H, Marquart KH, Luz A (1984) Oncogenic retrovirus from spontaneous murine osteomas. I. Isolation and biological characterization. J Gen Virol 65: 2237–2248
Schmidt J, Luz A, Erfle V (1988) Endogenous murine leukemia viruses: frequency of radiation-activation and novel pathogenic effects of viral isolates. Leuk Res 12: 393–403
Squire RA, Goodman DG, Valerio MG, Fredrickson T, Strandberg JD, Levitt MH, Lingeman CH, Harshbarger JC, Dawe CJ (1978) Tumors. In: Benirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol 2. Springer, Berlin, Heidelberg New York, pp 1051–1283
Stanton MF (1979) Tumours of the bone. In: Turusov VS et al. (eds) Pathology of tumours in laboratory animals, vol II. Tumours of the mouse. IARC Sci Publ 23: 577–609
Vaughan JM (1973) The effects of irradiation on the skeleton, Oxford University Press, Oxford
West JD, Lyon MF, Peters J, Selby PB (1985) Genetic differences between substrains of the inbred mouse strain 101 and designation of a new strain 102. Genet Res 46: 349–352
Wilson JT, Hauser RE, Ryffel B (1985) Osteomas in OF-1 mice: no alteration in biologic behavior during long-term treatment with cyclosporine. JCNI 75: 897–903
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Luz, A., Murray, A.B., Schmidt, J. (1991). Osteoma, Spontaneous and Virus-Induced, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_28
Download citation
DOI: https://doi.org/10.1007/978-3-642-76533-9_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76535-3
Online ISBN: 978-3-642-76533-9
eBook Packages: Springer Book Archive