Virus-Host Interactions and the Pathogenesis of Murine and Human Oncogenic Retroviruses

  • P. N. Tsichlis
  • P. A. Lazo
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 171)


Retroviruses are a heterogeneous group of plus strand RNA viruses which replicate their RNA genome through a DNA intermediate. During their life cycle the retroviruses interact with the host in a variety of ways. Thus, viral gene products interact with cellular proteins and modulate or subvert their function. Furthermore, the proviral DNA integrates into the cellular genome introducing mutations which alter the biology of the infected cell. These interactions between the virus and the host and the phenomena associated with them determine the pathogenicity of retroviruses (Lazo and Tsichlis 1990 and this volume).


Murine Leukemia Virus Avian Leukosis Virus Provirus Integration Friend Virus Cellular Oncogene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • P. N. Tsichlis
    • 1
  • P. A. Lazo
    • 1
  1. 1.Department of Medical OncologyFox Chase Cancer CenterPhiladelphiaUSA

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