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Insertional Mutagenesis in Mouse Mammary Tumorigenesis

  • Chapter
Retroviral Insertion and Oncogene Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 171))

Abstract

Over the past few years, several surprising discoveries have been made regarding cellular oncogenes which are activated in mouse mammary tumors. These genes provide a particularly good example of the theme of this volume: host cell oncogenes activated by insertion of proviral DNA. They belong especially to this group because most of them have been discovered by virtue of insertional activation, through the application of provirus tagging methods. Quite unexpectedly, what several mouse mammary tumor virus (MMTV) activated oncogenes have in common is that they appear to play key roles in early normal development. In this chapter, the properties of the genes, their products, and their role in embryogenesis will be reviewed (see also Nusse 1988a, b).

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Developmental Biology, Beckman Center, Stanford University, 94305, Stanford, CA, USA

    R. Nusse

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  1. R. Nusse
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  1. Dept. of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 2019 Adelbert Rd., 44106, Cleveland, OH, USA

    Hsing-Jien Kung

  2. Dept. of Microbiology, School of Medicine, University of Southern California, 2011 Zonal Avenue HMR-401, 90033-1054, Los Angeles, CA, USA

    Peter K. Vogt

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© 1991 Springer-Verlag Berlin Heidelberg

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Nusse, R. (1991). Insertional Mutagenesis in Mouse Mammary Tumorigenesis. In: Kung, HJ., Vogt, P.K. (eds) Retroviral Insertion and Oncogene Activation. Current Topics in Microbiology and Immunology, vol 171. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76524-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-76524-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76526-1

  • Online ISBN: 978-3-642-76524-7

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