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The Liver as Modulator of the Host-Defense Response: Host-Defense Failure Disease as a Manifestation of Hepatic Decompensation

  • Conference paper
Shock, Sepsis, and Organ Failure

Abstract

In this conference we are focusing on the relationship of the liver and the gut in the evolution of the post-injury septic process. However, I would like to refocus your attention on the liver as a critical organ modulating the entire host-defense response to trauma and to sepsis. Since the original studies of Tillet and Francis (1) which initiated our awareness of the presence of the process which we now call the acute phase response, we have become aware that the higher animal’s reaction to a localized but severe injury, or to its invasion by a bacterial or viral organism initiates an organized systemic host-defense response. When this host-defense response is appropriate to the stimulus, we see the initiation of a process which serves to control the initial disequilibrium introduced by the foreign stimulus and which acts to combat and eliminate invasive sepsis and to prevent septic decompensation. However, when this response process becomes disordered, we find ourselves dealing with what is truly a systemic disease of the acute phase response continued into a chronic decompensatory state, which we presently know as the Multiple Organ Failure Syndrome.

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Authors
  1. John H. Siegel M.D.
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag  & Heinz Redl  & 

  2. Maryland Institute for Emergency Medical Services Systems, Department of Surgery, Medical School, University of Maryland, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  3. School of Medicine, John Hopkins University, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  4. Shriners Burns Institute and The University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas, 77550, USA

    Daniel L. Traber

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© 1991 Springer-Verlag Berlin, Heidelberg

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Siegel, J.H. (1991). The Liver as Modulator of the Host-Defense Response: Host-Defense Failure Disease as a Manifestation of Hepatic Decompensation. In: Schlag, G., Redl, H., Siegel, J.H., Traber, D.L. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76511-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-76511-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53831-8

  • Online ISBN: 978-3-642-76511-7

  • eBook Packages: Springer Book Archive

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