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Pathogenetic Linkages between Gram Negative Septic Shock and the Cellular Initiation and Regulation of Coagulation

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Shock, Sepsis, and Organ Failure

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Abstract

Gram negative sepsis elicits complex pathophysiologic responses which are often severe and include disseminated intravascular coagulation and disseminated intravascular microthrombosis (DIC) within the context of hypotension, leukopenia, and a set of profound tissue injury associated with general cytokine generation and frequent local accumulation and activation of leukocytes and all to common terminal occurrence of multiple organ failure and death. DIC is common, not always fully established in the clinical setting or fully analyzed, and can frequently progress to a shock state and frequent death (McKay, 1964; Hinshaw and Cox, 1972).

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Authors and Affiliations

  1. Vascular Cell and Molecular Biology Program, Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California, USA

    Thomas S. Edgington

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  1. Thomas S. Edgington
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag  & Heinz Redl  & 

  2. Maryland Institute for Emergency Medical Services Systems, Department of Surgery, Medical School, University of Maryland, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  3. School of Medicine, John Hopkins University, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  4. Shriners Burns Institute and The University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas, 77550, USA

    Daniel L. Traber

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© 1991 Springer-Verlag Berlin, Heidelberg

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Edgington, T.S. (1991). Pathogenetic Linkages between Gram Negative Septic Shock and the Cellular Initiation and Regulation of Coagulation. In: Schlag, G., Redl, H., Siegel, J.H., Traber, D.L. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76511-7_14

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  • DOI: https://doi.org/10.1007/978-3-642-76511-7_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53831-8

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