Tissue Distribution and Repertoire Selection of Human γδT Cells: Comparison With the Murine System

  • J. Borst
  • Thea M. Vroom
  • J. D. Bos
  • J. J. M. Van Dongen
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 173)


With the discovery of T cell receptor (TCR) γδ, the question has arisen what contribution T cells expressing this receptor type make to the immune system. This question can also be formulated as follows: Do γδ T cells complement or overlap with αβ T cells with respect to 1) antigenic specificities (repertoire), 2) functions, and/or 3) sites of action within the body? In the murine and the human systems a great deal of data have been gathered regarding repertoire and tissue distribution of γδ T cells. In the mouse, there appears to be a connection between repertoire and tissue distribution, in that cells expressing TCR γδ characterized by certain Vγ and Vδ gene segments are preferentially localized in certain tissues. We have made an inventory of the tissue distribution of human γδ T cells and looked into the repertoire bias of peripheral human γδ T cells. Here, we would like to present a simplified picture of the species differences between man and mouse with respect to these two issues.


Gene Segment Junctional Diversity Human Intestinal Epithelium Intestinal Intraepithelial Lymphocyte Dendritic Epidermal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • J. Borst
    • 1
  • Thea M. Vroom
    • 2
  • J. D. Bos
    • 3
  • J. J. M. Van Dongen
    • 4
  1. 1.Division of ImmunologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Department of PathologyRotterdam Cancer CenterRotterdamThe Netherlands
  3. 3.Department of DermatologyAcademic Medical CenterAmsterdamThe Netherlands
  4. 4.Department of ImmunologyErasmus UniversityRotterdamThe Netherlands

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