Tissue Distribution and Repertoire Selection of Human γδT Cells: Comparison With the Murine System
With the discovery of T cell receptor (TCR) γδ, the question has arisen what contribution T cells expressing this receptor type make to the immune system. This question can also be formulated as follows: Do γδ T cells complement or overlap with αβ T cells with respect to 1) antigenic specificities (repertoire), 2) functions, and/or 3) sites of action within the body? In the murine and the human systems a great deal of data have been gathered regarding repertoire and tissue distribution of γδ T cells. In the mouse, there appears to be a connection between repertoire and tissue distribution, in that cells expressing TCR γδ characterized by certain Vγ and Vδ gene segments are preferentially localized in certain tissues. We have made an inventory of the tissue distribution of human γδ T cells and looked into the repertoire bias of peripheral human γδ T cells. Here, we would like to present a simplified picture of the species differences between man and mouse with respect to these two issues.
KeywordsMigration Acetone Dermatol Haas
Unable to display preview. Download preview PDF.
- Bonneville M, Itohara S, Krecko EG, Mombaerts P, Ishida I, Katsuki M, Berns A, Farr AG, Janeway CA, Tonegawa S (1990) Transgenic mice demonstrate that epithelial homing of γ/δ T cells is determined by cell lineages independent of T cell receptor specificity. J Exp Med 171:1015–1026.PubMedCrossRefGoogle Scholar
- Ciccone E, Ferrini S, Bottino C, Viale O, Progione I, Pantaleo G, Tambussi G, Moretta L (1988) A monoclonal antibody specific for a common determinant on the human T cell receptor γ/δ directly activates CD3+ WT31− lymphocytes to express their functional programs. J Exp Med 168:1–11.PubMedCrossRefGoogle Scholar