Abstract
In addition to Langerhans cells, the epidermis of all strains of normal mice harbors another population of bone marrow-derived dendritic cells. Because of their abundant expression of surface-bound Thy-1 antigens these CD45+, asialo-GM1+, la-, CD4-, CD5-, CD8- cells have originally been referred to as Thy-1+ dendritic epidermal cells (Thy-1+ DEC; Romani et al., 1985). The original assumption that Thy-1+ DEC belong to the T cell lineage was proven conclusively with the subsequent demonstration that the overwhelming majority of Thy-1+ DEC in normal adult epidermis expressed CD3-associated TCR γ/δ heterodimers (Stingl et al., 1987; Steiner et al., 1988). In view of this finding, we have proposed that Thy-1+ DEC should be renamed dendritic epidermal T cells (DETC; Steiner et al., 1988).
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© 1991 Springer-Verlag Berlin · Heidelberg
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Stingl, G., Elbe, A., Paer, E., Kilgus, O., Strohal, R., Schreiber, S. (1991). The Role of Fetal Epithelial Tissues in the Maturation/Differentiation of Bone Marrow-Derived Precursors into Dendritic Epidermal T Cells (DETC) of the Mouse. In: Pfeffer, K., Heeg, K., Wagner, H., Riethmüller, G. (eds) Function and Specificity of γ/δ T Cells. Current Topics in Microbiology and Immunology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76492-9_37
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DOI: https://doi.org/10.1007/978-3-642-76492-9_37
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