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Phenotypic and Functional Heterogeneity of Double Negative (CD4-CD8-) αβ TcR+ T Cell Clones

  • J. G. Murison
  • Sonia Quaratino
  • M. Londei
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 173)

Abstract

The CD4 and CD8 T cell markers are useful phenotypic landmarks which in general terms divide the T cell pool into those cells which aid B cell responses and T cells with cytotoxic capabilities. CD4+ T cells respond to antigen in the context of class II MHC and are predominantly helpers of B cell responses whereas CD8+ T cells are stimulated by antigen in the context of class I MHC and function as cytotoxic T cells. It has been assumed that all mature T cells express either of these markers, however, recently a T cell subpopulation has been described which lack both CD4 and CD8. The majority of these double negative T cells bear the alternative γδ T cell receptor (TcR) with between 7% (Bender and Kabelitz, 1990) and 38% (Scott, 1990) being αβ T cell receptor positive. T cells with this phenotype are known to exist in the thymus but are thought to be immature and destined to either die or differentiate into mature single-positive (CD4+ CD8 or CD4 CD8+) T cells. Therefore their existence in the periphery indicates either the existence of a novel mature T cell subset or leakage of immature cells from the thymus.

Keywords

Lupus Nephritis Cell Clone Peripheral Blood Mononuclear Chromium Release Assay Double Negative Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • J. G. Murison
    • 1
  • Sonia Quaratino
    • 1
  • M. Londei
    • 1
  1. 1.Charing Cross Sunley Research CentreHammersmith, LondonEngland

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