Abstract
The majority of T cells express the αβ T-cell receptor (TCR) that recognizes antigen in the context of the major histocompatibility complex (MHC). The repertoire of αβ T cells reflects the diversity of potential environmental antigens and the polymorphism of MHC molecules. A minor subset of T cells expresses the γδ TCR. Although human peripheral blood γδ T cells display great junctional diversity of the γ and δ chains, only a limited combinatorial diversity of variable (V) region usage has been recorded (reviewed by Triebel and Hercend 1989). Moreover, recent reports indicate that several human γδ T-cell lines and a large proportion of murine γδ T cells recognize heat shock proteins (hsps) in mycobacterial extracts (O’Brien et al. 1989; Holoshitz et al. 1989; Haregewoin et al. 1989). Therefore, it was suggested that the antigens and the antigen presenting molecules for γδ T cells could be relatively non-polymorphic (reviewed by Born et al. 1990).
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© 1991 Springer-Verlag Berlin · Heidelberg
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Fisch, P. et al. (1991). Function and Specificity of Human Vγ9/Vδ2 T Lymphocytes. In: Pfeffer, K., Heeg, K., Wagner, H., Riethmüller, G. (eds) Function and Specificity of γ/δ T Cells. Current Topics in Microbiology and Immunology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76492-9_24
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DOI: https://doi.org/10.1007/978-3-642-76492-9_24
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