Abstract
Human T cell differentiation is believed to occur largely in the thymus. (However, the occurrence of some extrathymic differentiation sites(s), particularly for cells expressing TCRγδ, has been suggested. For example, in adults where the thymus has involute, T cell development nevertheless continues; one evidence is the reconstitution of the T cell repertoire after bone marrow transplantation.) The following studies represent our initial effort to investigate the role of the human thymus in T cell differentiation in vitro, especially in the development of TCRγδ cells.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Groh, V., Fabbi, M., Stromminger, J.L. (1991). Development of Human T Cells Expressing TCR γδ In Vitro. In: Pfeffer, K., Heeg, K., Wagner, H., Riethmüller, G. (eds) Function and Specificity of γ/δ T Cells. Current Topics in Microbiology and Immunology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76492-9_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-76492-9_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76494-3
Online ISBN: 978-3-642-76492-9
eBook Packages: Springer Book Archive