Lack of Alloantigen-Specific Cytotoxic T Cell Activity in the TCR-γδT Cell Subpopulation of Alloantigen-Immune Chickens

  • J. Cihak
  • H. Merkle
  • U. Lösch
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 173)


Recently T cell receptor (TCR) homologues of the mammalian TCR-αβ (TCR2) and the TCR-γδ(TCR1) have been defined in the chicken (Sowder et al. 1988; Cihak et al. 1988; Chen et al. 1988), where the TCR1 cells may constitute approximately 20–65 % of the T cell pool (Cihak et al. in preparation). In addition to the TCRl and TCR2 cells a third subpopulation of T cells has been identified in the chicken (Chen et al. 1989; Cooper et al. 1989). These cells, provisionally named “TCR3” cells, are TCR-αβ T cells which use the Vß2 gene product whereas TCR2 cells use the Vßl gene product (M.D. Cooper, personal communication and in this issue).


Spleen Cell TCR2 Cell Negative Selection Method Irrelevant Isotype Control Chicken Spleen Cell 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • J. Cihak
    • 1
  • H. Merkle
    • 1
  • U. Lösch
    • 1
  1. 1.Institute of Animal PhysiologyUniversity of MunichMünchen 22Germany

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