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Signal Transduction in Photoreceptor Cells pp 160–171Cite as

Mechanisms of β-Adrenergic Receptor Desensitization

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Part of the book series: Research Reports in Physics ((RESREPORTS))

Abstract

β-Adrenergic receptors mediate the stimulatory effects of catecholamines on adenylyl cyclase. They are members of the large family of cell surface receptors transmitting their signals via G-proteins, which all have a characteristic structure encompassing seven transmembrane alpha-helical domains. These receptors are subject to a multitude of regulatory mechanisms that serve to adapt receptor responsiveness to the level of receptor stimulation. Agonist stimulation of the receptors results in a loss of receptor responsiveness which is called desensitization. Rapid mechanisms of desensitization involve a loss of receptor function by receptor phosphorylation plus binding of a protein inhibiting receptor-G protein interaction. This protein was called β-arrestin, because it is similar to the retinal protein arrestin that has been proposed to inhibit rhodopsin function. Slow mechanisms of desensitization involve a reduction in receptor number, which is due to both enhanced receptor degradation and reduced synthesis.

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Author information

Authors and Affiliations

  1. Laboratorium für Molekulare Biologie, Universität München, Germany

    M. J. Lohse

  2. Max-Planck-Institut für Biochemie, W-8033, Martinsried, Fed.Rep.of Germany

    M. J. Lohse

Authors
  1. M. J. Lohse
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Editor information

Editors and Affiliations

  1. Department of Ophthalmology and Department of Biochemistry and Molecular Biology, University of Florida, 32610, Gainesville, Florida, USA

    Paul A. Hargrave

  2. Institut für Biophysik und Strahlenbiologie, Universität Freiburg, Albertstraße 23, W-7800, Freiburg, Fed. Rep. of Germany

    Klaus Peter Hofmann

  3. Institut für Biologische Informationsverarbeitung, KFA Jülich, Postfach 1913, W-5170, Jülich, Fed. Rep. of Germany

    U. Benjamin Kaupp

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© 1992 Springer-Verlag Berlin Heidelberg

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Lohse, M.J. (1992). Mechanisms of β-Adrenergic Receptor Desensitization. In: Hargrave, P.A., Hofmann, K.P., Kaupp, U.B. (eds) Signal Transduction in Photoreceptor Cells. Research Reports in Physics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76482-0_12

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  • DOI: https://doi.org/10.1007/978-3-642-76482-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53765-6

  • Online ISBN: 978-3-642-76482-0

  • eBook Packages: Springer Book Archive

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