Abstract
Under conventional insulin therapy, morbidity and mortality in type I diabetic patients is still high [20]. Prerequisite for prevention of diabetic complications is long-term normoglycemia [5]. However, normal glucose homeostasis is up to now still only achievable with pancreatic grafting [10]. In recent years, pancreatic transplantation is quite a safe and successful mode of treatment for carefully selected type I diabetics [13,14,17].
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References
Barbosa J, King R, Noreen H, Yunis EJ (1977) The histocompatibility system in juvenile insulin-dependent diabetic multiplex kindreds. J Clin Invest 60:989–998.
Bolinder J, Gunnarsson R, Tydén G, Brattström C, Östman J, Groth CG (1988) Metabolic effects of living related pancreatic graft donation. Transplant Proc 20:475–478.
Chinn PL, Sutherland DER, Goetz FC, Oliphant UJ, Elick BA, Najarian JS (1984) Metabolic effect of hemipancreatectomy in living related graft donors. Transplatn Proc 16:11–17.
Dubernard JM, Sutherland DER (eds) (1989) International Handbook of Pancreas Transplantation. Kluwer, Dordrecht.
Hanssen KF, Dahl Jørgensen K, Lauritzen T, Feldt-Rasmussen B, Brinchmann-Hansen O, Deckert T (1986) Diabetic control and microvascular complications: The nearnormoglycemic experience. Diabetologia 29:677–684.
ImamuraT, Koffler M, Helderman JH, Prince D, Thirlby R, Inman L, Unger RH (1988) Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia. Diabetes 37:600–609.
Kendall DM, Sutherland DER, Goetz FC, Najarian JS (1989) Metabolic effect of hemipancratectomy in donors. Preoperative prediction of postoperative oral glucose tolerance. Diabetes 38 [Suppl 1]:101–103.
Kendall DM, Sutherland DER, Najarian JS, Goetz FC, Robertson RP (1990) Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N Engl J Med 322:898–903.
Köbberling J, Tillil H (1982) Empirical risk figures for first degree relatives of non-insulin dependent diabetics. In: Köbberling J and Tattersall R (eds) The genetics of diabetes mellitus. Academic, London, pp 201–209.
Landgraf R, Nusser J, Scheuer R, Fiedler A, Scheider A, Meyer-Schwickerath E, Miiller-Felber W, Illner WD, Abendroth D, Land W (1989) Metabolic control and effect of secondary complications of diabetes mellitus by pancreatic transplantation. Ballière’s Clinical Gastroenterology 3:865–876.
Leaky JL, Bonner Weir S, Weir GC (1988) Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 81:1407–1414.
Mizumoto R, Kawarada Y, Goshima H, Tamaki T, Sekoguchi T, Tomikawa J (1982) Carbohydrate metabolism and endocrine function in the pancreas remnant after major pancreatic resection. Am J Surgery 143:237–243.
Land W, Landgraf R (1987) Clinical pancreas transplantation: The world experience. Transplant Proc 19 [Suppl 4]:1–102.
Najarian JS, Sutherland DER, Groth CG (Guest Eds) (1990) Second International Congress on Pancreatic and Islet Cell Transplantation. Transplant Proc 22:569–883.
Sun AM, Coddling JA, Haist RE (1974) A study of glucose tolerance and insulin response in partially depancreatized dogs. Diabetes 23:424–432.
Sutherland DER, Sibley R, Chinn P, Michael A, Srikanta S, Taub F, Najarian J, Goetz FC (1984) Twin to twin pancreas transplantations: reversal and reenactment of the pathogenesis of type I diabetes. Clin Res 32:56.
Sutherland DER, Dunn DL, Goetz FC, Kennedy W, Ramsay RC, Steffes MW, Mauer SM, Gruessner R, Moudry-Munns KC, Morel P, Viste A, Robertson RP, Najarian JS (1989) 10-year experience with 290 pancreas transplants at a single institution. Ann Surgery 210:274–288.
Ward WK, Wallum BJ, Beard JC, Taborsky Jr GJ, Porte Jr D (1988) Reduction of glycemic potentiation. Sensitive indicator of β-cell loss in partially pancreatectomized dogs. Diabetes 37:723–729.
Weir GC, Bonner Weir S, Leaky JL (1990) Islet mass and function in diabetes and transplantation. Diabetes 39:401–405.
WHO Study Group (1985) Diabetes mellitus. WHO Technical Report Series 727.
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© 1991 Springer-Verlag Berlin Heidelberg
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Landgraf, R. (1991). Medical Risk and Benefit in Living Pancreas Segment Donors. In: Land, W., Dossetor, J.B. (eds) Organ Replacement Therapy: Ethics, Justice Commerce. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76444-8_19
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DOI: https://doi.org/10.1007/978-3-642-76444-8_19
Publisher Name: Springer, Berlin, Heidelberg
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