Abstract
There is an ever increasing discrepancy between the demand for renal transplantation and the supply of donor organs [1, 2]. Much of the recent increase in transplant waiting lists has been due to a rise in older patients (over 50 years). One possible solution to the shortage of cadaver donor organs would be to increase the use of living donors [3]. Recent studies have suggested that older living donors are an important source of organs [4, 5], however, physiological studies suggest that functional renal tissue decreases with age [6, 7]. Analyses of multicentre data [8] have also confirmed earlier reports [9] indicating that donor recipient age difference is a risk factor for graft survival, particularly when transplanting older donor organs. A survey was undertaken to investigate the extent of living donor transplantation (LDT) in the United Kingdom and Ireland with special reference to graft survival and the relative ages of donors and recipients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Feest TG, Mistry CD, Grimes DS et al. (1990) Incidence of advanced chronic renal failure and the need for end-stage renal replacement treatment. Br Med J 301:897–900.
Broyer M, Brunner FP, Brynger H et al. (1987) EDTA Registry Centre Survey 1985. Nephrol Dial Transplant 2:475–487.
Bay WJ, Lee AH (1987) The living donor in kidney transplantation. Ann Int Med 106:719–727.
Compistol JM, Manalich M, Andrea J (1989) Rising age limit for kidney donors. Lancet ii:744–745.
Fauchald P, Sodal G, Albrechsten H et al. (1991) The use of elderly living donors (LD) in renal transplantation. Transplant Proc (in press).
Anderson S, Brenner BM (1986) Effects of ageing on the renal glomerulus. Am J Med 80:435–442.
O’Conner KJ, Franklin C, Bradley JW (1986) The effect of increasing donor age on kidney transplant outcome. Transplant Proc 18:480–481.
Thorogood J, Persijn GG, Zantvoort FA (1990) Matching for age in renal transplantation. N Engl J Med 332:852–853.
Donnelly PK, Simpson AR, Nicholson M et al. (1989) Age-matching improves the results of renal transplantation with older donors. Br J Surg 12:1349–1350.
Peto R (1973) Experimental survival curves for interval censored data. Appl Stat 23:86–91.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Donelly, P.K., Simpson, A.R., Clayton, D.G. (1991). Living Donor Kidney Transplantation in the United Kingdom and Ireland: Does Donor-Recipient Age Difference Matter?. In: Land, W., Dossetor, J.B. (eds) Organ Replacement Therapy: Ethics, Justice Commerce. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76444-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-76444-8_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76446-2
Online ISBN: 978-3-642-76444-8
eBook Packages: Springer Book Archive