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Reperfusion of Ischemic Brain: Why and Why Not!

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Book cover Thrombolytic Therapy in Acute Ischemic Stroke

Abstract

Since the time of William Harvey, physiologists, anatomists, and clinicians alike have viewed the heart and circulatory system as supporting actors whose role it was to provide blood to the various organs of the body. Arguably the principal organ supplied is the brain, which controls the perceptions, thoughts, and actions of the body. Clearly, the raison d’etre of the arteries coursing to the brain is to supply blood which carries fuel, mainly sugar and oxygen, to nervous system structures which cannot function without it. When an artery is blocked, even temporarily, the brain is deprived of fuel and stops working just as a car would without gas. If fuel is lacking for long enough, the brain wilts, softens, and dies. Some components seem more vulnerable to the lack of fuel supply and die before others.

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Author information

Authors and Affiliations

  1. Department of Neurology, New England Medical Center Hospitals, Tufts University, 750 Washington Street, 02111, Boston, MA, USA

    L. R. Caplan

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  1. L. R. Caplan
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Editor information

Editors and Affiliations

  1. Neurologische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg, Germany

    Werner Hacke  & Matthias Hirschberg  & 

  2. Department of Molecular and Experimental Medicine and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Gregory J. del Zoppo MD

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© 1991 Springer-Verlag Berlin Heidelberg

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Caplan, L.R. (1991). Reperfusion of Ischemic Brain: Why and Why Not!. In: Hacke, W., del Zoppo, G.J., Hirschberg, M. (eds) Thrombolytic Therapy in Acute Ischemic Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76439-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-76439-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53680-2

  • Online ISBN: 978-3-642-76439-4

  • eBook Packages: Springer Book Archive

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