Abstract
Local fibrinolytic therapy using interventional neuroradiological techniques give a new chance in therapy in acute stroke [8]. In particular, vertebrobasilar disturbances are important indications [7], Local lysis, however, is often difficult, time-consuming, and needs permanent attention by specially trained staff. Thus the positive results of systemic fibrinolytic therapy in myocardial infarction (e. g., [6]) have resulted in new studies using clot-specific agents, particularly recombinant tissue plasminoge activator (rt-PA) in stroke. Experience gained in treating acute myocardial infarction (AMI), with prourokinase (PUK), and especially the low incidence of bleeding complications (e. g., [2]), led to the use of PUK in stroke therapy. In this contribution, results from five patients treated with PUK as a clot-specific agent are presented. Target points were the clinical time-course and the monitoring of fibrinolytic effects.
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© 1991 Springer-verlag Berlin Heidelberg
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Hamann, G., Haass, A., Pindur, G., Wenzel, E., Schimrigk, K. (1991). Prourokinase Therapy in Stroke. In: Hacke, W., del Zoppo, G.J., Hirschberg, M. (eds) Thrombolytic Therapy in Acute Ischemic Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76439-4_38
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DOI: https://doi.org/10.1007/978-3-642-76439-4_38
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