Treatment of Acute Ischemic Stroke with Recombinant Tissue Plasminogen Activator: Evaluation with Regional Cerebral Blood Flow Single Photon Emission Computed Tomography

  • D. Herderschee
  • M. Limburg
  • A. Hijdra
  • E. A. van Royen
  • P. A. Koster
Conference paper

Abstract

The objectives of the study described in this contribution were to run a pilot study on the efficacy and safety of recombinant tissue plasminogen activator (rt-PA) treatment in patients with intermediate MCA ischemic lesions and to assess the efficacy of perfusion with noninvasive neuroimaging with technetium-99 m hexamethyl propyleneamine oxime (TcHMPAO) regional cerebral blood flow (rCBF) single photon emission computed tomography (SPECT).

Keywords

Ischemia Propylene Heparin Plasminogen Oxime 

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References

  1. 1.
    Jang IK, Gold HK, Ziskind AA, Fallon JT, Holt RE, Leinbach RC, May JW, Collen D (1989) Differential sensitivity of erythrocyte-rich and platelet-rich arterial thrombi to lysis with rTPA. Circulation 79:920–928PubMedCrossRefGoogle Scholar
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    Limburg M, van Royen EA, Hijdra A, de Bruine JF, Verbeeten BWJ (1990) Regional cerebral blood flow, single photon emission computed tomography and early death in acute ischemic stroke. Stroke 21:1150–1155PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. Herderschee
    • 1
  • M. Limburg
    • 1
  • A. Hijdra
    • 1
  • E. A. van Royen
    • 2
  • P. A. Koster
    • 2
  1. 1.Department of NeurologyAcademisch Medisch CentrumAmsterdamThe Netherlands
  2. 2.Department of Diagnostic RadiologyAcademisch Medisch CentrumAmsterdamThe Netherlands

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