Fibrinolysis in Myocardial Infarction: Lessons for Cerebrovascular Disease

  • J. Meyer
Conference paper


Until about 15 years ago the prevailing view of the pathogenesis of acute myocardial infarction was that it was based on total or subtotal atherosclerotic coronary obstructions causing a major decrease in antegrade flow. Fresh thrombi, which were often found during autopsy, were thought to be the result rather than the cause of the infarction [4], With the increasing availability of coronary arteriography for acute myocardial infarction came a major change in the understanding of the pathophysiology of the disease. DeWood et al. [9], using serial coronary arteriograms, showed that a fresh, occluding coronary thrombus is the cause and can be found in the majority of acute myocardial infarctions. While within the first 6 h the rate of total occlusions was 85%, this fell to 68% in the 6th–12th h — and to 64% in the 12th–24th h. These results also demonstrated that spontaneous thrombolysis occurs in about 20% of all patients within the 1st day.


Acute Myocardial Infarction Thrombolytic Agent Thrombolytic Treatment Recombinant Tissue Plasminogen Activator Acute Myocardial Infarc 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • J. Meyer
    • 1
  1. 1.Second Medical University ClinicMainz 1Germany

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