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Fibrinolysis in Myocardial Infarction: Lessons for Cerebrovascular Disease

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Thrombolytic Therapy in Acute Ischemic Stroke

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Abstract

Until about 15 years ago the prevailing view of the pathogenesis of acute myocardial infarction was that it was based on total or subtotal atherosclerotic coronary obstructions causing a major decrease in antegrade flow. Fresh thrombi, which were often found during autopsy, were thought to be the result rather than the cause of the infarction [4], With the increasing availability of coronary arteriography for acute myocardial infarction came a major change in the understanding of the pathophysiology of the disease. DeWood et al. [9], using serial coronary arteriograms, showed that a fresh, occluding coronary thrombus is the cause and can be found in the majority of acute myocardial infarctions. While within the first 6 h the rate of total occlusions was 85%, this fell to 68% in the 6th–12th h — and to 64% in the 12th–24th h. These results also demonstrated that spontaneous thrombolysis occurs in about 20% of all patients within the 1st day.

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Author information

Authors and Affiliations

  1. Second Medical University Clinic, Langenbeckstraße 1, W-6500, Mainz 1, Germany

    J. Meyer

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  1. J. Meyer
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Editor information

Editors and Affiliations

  1. Neurologische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg, Germany

    Werner Hacke  & Matthias Hirschberg  & 

  2. Department of Molecular and Experimental Medicine and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Gregory J. del Zoppo MD

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© 1991 Springer-Verlag Berlin Heidelberg

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Meyer, J. (1991). Fibrinolysis in Myocardial Infarction: Lessons for Cerebrovascular Disease. In: Hacke, W., del Zoppo, G.J., Hirschberg, M. (eds) Thrombolytic Therapy in Acute Ischemic Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76439-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-76439-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53680-2

  • Online ISBN: 978-3-642-76439-4

  • eBook Packages: Springer Book Archive

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