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Update on Animal Model Experience with Recombinant Tissue Plasminogen Activator

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Thrombolytic Therapy in Acute Ischemic Stroke

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Abstract

Animal experiments have demonstrated that release of vessel occlusion with early restoration of blood flow frequently diminishes cerebral infarct size [13]. The recognition of potentially reversible cerebral blood flow thresholds has led to the concept of the ischemic penumbra [1]. The time during which brain tissue can remain in this penumbral state without suffering definitive damage is still a matter of debate ([12, 16], Siesjö, this volume).

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Author information

Authors and Affiliations

  1. Neurologische Universitätsklinik Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg, Germany

    M. Hirschberg

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  1. M. Hirschberg
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Editor information

Editors and Affiliations

  1. Neurologische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg, Germany

    Werner Hacke  & Matthias Hirschberg  & 

  2. Department of Molecular and Experimental Medicine and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Gregory J. del Zoppo MD

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© 1991 Springer-Verlag Berlin Heidelberg

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Hirschberg, M. (1991). Update on Animal Model Experience with Recombinant Tissue Plasminogen Activator. In: Hacke, W., del Zoppo, G.J., Hirschberg, M. (eds) Thrombolytic Therapy in Acute Ischemic Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76439-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-76439-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53680-2

  • Online ISBN: 978-3-642-76439-4

  • eBook Packages: Springer Book Archive

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