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Thrombolytic Therapy in Ischemic Stroke: Relevance and Limitations of Animal Models

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Thrombolytic Therapy in Acute Ischemic Stroke

Abstract

We have recently asked the question: “why model stroke?” [29] in reaction to still further proliferation of new devices and techniques for inducing infarction. Currently the combinations of methodologies and various animal species have produced options as variable as the natural history of stroke itself. Indeed we may select the model that gives us the results we want. Unfortunately it is the enthusiasm generated by such planned optional results that places patients at risk in premature clinical trials [7, 12, 23].

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Author information

Authors and Affiliations

  1. Department of Neurology, George Washington University, 2150 Pennsylvania Avenue , 20037, NW, Washington DC, USA

    G. F. Molinari

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  1. G. F. Molinari
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Editors and Affiliations

  1. Neurologische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg, Germany

    Werner Hacke  & Matthias Hirschberg  & 

  2. Department of Molecular and Experimental Medicine and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Gregory J. del Zoppo MD

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© 1991 Springer-Verlag Berlin Heidelberg

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Molinari, G.F. (1991). Thrombolytic Therapy in Ischemic Stroke: Relevance and Limitations of Animal Models. In: Hacke, W., del Zoppo, G.J., Hirschberg, M. (eds) Thrombolytic Therapy in Acute Ischemic Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76439-4_12

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  • DOI: https://doi.org/10.1007/978-3-642-76439-4_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53680-2

  • Online ISBN: 978-3-642-76439-4

  • eBook Packages: Springer Book Archive

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