Improved Left Ventricular Geometry and Function by Prolonged Nitroglycerin Therapy After Acute Myocardial Infarction

  • B. I. Jugdutt
  • B. L. Michorowski
  • W. T. Tymchak
Conference paper

Abstract

Early therapy with intravenous nitroglycerin during acute myocardial infarction reduces infarct expansion experimentally and clinically [1, 2]. However, the healing process after myocardial infarction takes place over 6 weeks in the dog model, with early expansion and late thinning [3, 4], and even longer in humans [4]. The aim of this study was therefore to test the hypothesis that prolonged reduction of preload and afterload during the healing phase after a first anterior transmural acute myocardial infarction (ATAMI) might further improve left ventricular (LV) geometry and function [5, 6].

Keywords

Placebo Glycerin Cardiol Creatine Washout 

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References

  1. 1.
    Jugdutt BI (1985) Delayed effects of early infarct-limiting therapies on healing after myocardial infarction. Circulation 72: 907–914PubMedCrossRefGoogle Scholar
  2. 2.
    Jugdutt BI, Warnica JW (1988) Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion and complications: Effect of timing, dosage, and infarct location. Circulation 78: 906–919PubMedCrossRefGoogle Scholar
  3. 3.
    Jugdutt BI, Amy RW (1988) Healing after myocardial infarction in the dog: Changes in infarct hydroxyproline and topography. J Am Coll Cardiol 7: 91–102CrossRefGoogle Scholar
  4. 4.
    Jugdutt BI (1987) Left ventricular rupture threshold during the healing phase after myocardial infarction in the dog. Can J Physiol Pharmacol 65: 307–316PubMedCrossRefGoogle Scholar
  5. 5.
    Michorowski BL, Tymchak WT, Jugdutt BI (1987) Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction, (abstract) Circulation 76 (Suppl IV): IV–128Google Scholar
  6. 6.
    Jugdutt BI, Michorowski BL, Tymchak WJ (1989) Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction. Z Kardiol 78 (Suppl 2): 127–129PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • B. I. Jugdutt
  • B. L. Michorowski
  • W. T. Tymchak

There are no affiliations available

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