Early therapy with intravenous nitroglycerin during acute myocardial infarction reduces infarct expansion experimentally and clinically [1, 2]. However, the healing process after myocardial infarction takes place over 6 weeks in the dog model, with early expansion and late thinning [3, 4], and even longer in humans . The aim of this study was therefore to test the hypothesis that prolonged reduction of preload and afterload during the healing phase after a first anterior transmural acute myocardial infarction (ATAMI) might further improve left ventricular (LV) geometry and function [5, 6].
Left Ventricular Ejection Fraction Creatine Kinase Thickness Ratio Left Ventricular Volume Ventricular Geometry
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Jugdutt BI (1985) Delayed effects of early infarct-limiting therapies on healing after myocardial infarction. Circulation 72: 907–914PubMedCrossRefGoogle Scholar
Jugdutt BI, Warnica JW (1988) Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion and complications: Effect of timing, dosage, and infarct location. Circulation 78: 906–919PubMedCrossRefGoogle Scholar
Jugdutt BI, Amy RW (1988) Healing after myocardial infarction in the dog: Changes in infarct hydroxyproline and topography. J Am Coll Cardiol 7: 91–102CrossRefGoogle Scholar
Jugdutt BI (1987) Left ventricular rupture threshold during the healing phase after myocardial infarction in the dog. Can J Physiol Pharmacol 65: 307–316PubMedCrossRefGoogle Scholar
Michorowski BL, Tymchak WT, Jugdutt BI (1987) Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction, (abstract) Circulation 76 (Suppl IV): IV–128Google Scholar
Jugdutt BI, Michorowski BL, Tymchak WJ (1989) Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction. Z Kardiol 78 (Suppl 2): 127–129PubMedGoogle Scholar