Skip to main content
SpringerLink
Log in

Selektive Chemoembolisation von primären und sekundären Lebermalignomen mit Mitomycin C, Lipiodol und Dura

  • Chapter
Neue Entwicklungen in der Therapie von Lebertumoren

Zusammenfassung

Die durchschnittliche Überlebenszeit von Patienten mit inoperablen primären Leberkarzinomen beträgt ohne Behandlung 75 Tage im Median [30]. Ebenso wird eine 6monatige mediane Überlebenszeit bei Patienten mit kolorektalen Lebermetastasen (CLRM) erwartet [3]. Systemische Therapien führten bisher nicht zu einer marginalen Verlängerung der Überlebenszeiten [27]. Nach regionaler Applikation von FUDR (Floxuridine) über die Leberarterie wurde dagegen eine Steigerung auf 16–19 Monate für kolorektale Karzinome beschrieben [8]. Die regionale Chemotherapie von Leberzellkarzinomen (LZK) hat sich im Gegensatz dazu nicht durchgesetzt. Aufgrund der hohen lokalen Toxizität des am häufigsten verwendeten Doxorubicins traten oft Komplikationen im zuführenden Gefäßsystem auf [18].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Abrahams HL (1964) The response of neoplastic renal vessels to epinephrine in man. Radiology 82:217–223

    Google Scholar 

  2. Bengmark S, Rosengreen K (1970) Angiographic study of the collateral circulation to the liver after ligation of the hepatic artery in man. Am J Surg 119: 620–624

    Article  CAS  PubMed  Google Scholar 

  3. Bengtsson G, Carlson G, Hafström L, Jönssen PE (1981) Natural history of patients with untreated liver metastases from colorectal cancer. Am J Surg 181:586–589

    Article  Google Scholar 

  4. Blumgart LH, Allison DJ (1982) Resection and embolization in the management of secondary hepatic tumors. World J Surg 6:32–45

    Article  CAS  PubMed  Google Scholar 

  5. Daniels J, Daniels A, Quinn M et al. (1988) Phase I trial with cisplatin or mitomycin hepatic chemoembolisation (CE) with angiostat collagen for embolisation (CFE) in patients with colo-rectal cancer. Proc ASCO 7:101

    Google Scholar 

  6. Dayon D, Mouzon A, Jourde AM, Regensberg C, Frileux C (1974) L’embolisation arterielle hepatique dans les tumeurs malignes du foie. Ann Radiol 17:593–603

    Google Scholar 

  7. Goldstein HM, Wallace S, Anderson JH, Bree RL, Gianturco C (1976) Transcatheter occlusion of abdominal tumors. Radiology 120:539–545

    CAS  PubMed  Google Scholar 

  8. Hottenrott C, Lorenz M (1987) Stellenwert der regionalen Chemotherapie der Leber. Z Gastroenterol 25:364–373

    CAS  PubMed  Google Scholar 

  9. Hottenrott C, Liermann D, Lorenz M (1988) Gezielte Beeinflussung der Lebergefäße mittels Noradrenalin zur Durchführung selektiver Tumortherapien in der Leber. Z Gastroenterol 26:35–36

    Google Scholar 

  10. Iwai K, Malda H, Konno T (1984) Use of oily contrast medium for selective drug targeting to tumor-enhanced therapeutic effect and x-ray image. Cancer Res 44:2115–2121

    CAS  PubMed  Google Scholar 

  11. Iwaki A, Nagasue N, Kobayashi M, Inokuchi K (1978) Intra-arterial chemotherapy with concomitant use of vasoconstrictors for liver cancer. Cancer Treat Rep 62:145–146

    CAS  PubMed  Google Scholar 

  12. Kobayashi H, Inove H, Shimada J, Yano T, Maeda T, Oyama T, Shinora S (1987) Intra-arterial injection of adriamycin/mitomycin C, lipiodol suspension in liver metastases. Acta Radiol 28:275–280

    Article  CAS  PubMed  Google Scholar 

  13. Konno T, Maeda H, Iwai K (1983) Effect of arterial administration of high-molecular-weight anticancer agents SMANC with lipid lymphographic agent on hepatoma: A preliminary report. Eur J Cancer Clin Oncol 19:1053–1065

    Article  CAS  PubMed  Google Scholar 

  14. Konno T, Maeda H, Iwai K, Maki S, Tashiro MS, Uchida M, Miyauchi Y (1984) Selective targeting of anti-cancer drug and simultane image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer 54:2374

    Article  Google Scholar 

  15. Lang EK (1970) Superselective arterial catheterization of tumors of the urogenitaltract: A modality used for perfusion with chemotherapeutic agents and infarction with radioactive pellets. J Urol 104:16–25

    CAS  PubMed  Google Scholar 

  16. Leger L, Buchet R, Bitry-Boely C, Premont M (1961) Introduction à l’études de, la lymphographie hepatique. Presse Med 69:1981–1982

    CAS  PubMed  Google Scholar 

  17. Maraj R, Kew MC, Hyslop RJ (1988) Resectability rate of hepatocellular carcinoma in rural Southern Africans. Br J Surg 75:335–338

    Article  CAS  PubMed  Google Scholar 

  18. Meier P (1990) Persönliche Mitteilung

    Google Scholar 

  19. Miller DL, O’Leary TJ, Girton M (1987) Distribution of iodized oil within the liver after hepatic arterial injection. Radiology 162:849–852

    CAS  PubMed  Google Scholar 

  20. Nakakuma K, Tashiro S, Uemara K (1979) Studies on the anticancer treatment with oily anticancer drug injected into the ligated hepatic artery for liver cancer. Nichidoku Iho 24:675–682

    Google Scholar 

  21. Nakakuma K, Tashiro S, Hiraoka T, Ogata K, Ootsuka K (1985) Hepatocellular carcinoma and metastatic cancer detected by iodized oil. Radiology 154:15–17

    CAS  PubMed  Google Scholar 

  22. Nakamura H, Hashimoto T, Oi H, Swada S (1989) Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 170:783–786

    CAS  PubMed  Google Scholar 

  23. Nilsson LA (1966) Therapeutic hepatic artery ligation in patients with secondary liver tumors. Rev Surg 23:374–376

    CAS  PubMed  Google Scholar 

  24. Papadimitrou JM, Woods AE (1975) Structural and functional characteristics of the microcirculation in neoplasm. J Pathol 65:116–121

    Google Scholar 

  25. Raoul JL, Bourget P, Bretagne JF et al. (1988) Hepatic artery injection of I-131-labeled lipiodol-part 1-biodistribution study in patients with hepatocellular carcinoma and liver metastases. Radiology 168:541–545

    CAS  PubMed  Google Scholar 

  26. Sasaki Y, Imaoka S, Kusugai H et al. (1987) A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin and gelating sponge. Cancer 60:1194–1203

    Article  CAS  PubMed  Google Scholar 

  27. Scheithauer W (1989) Palliative Chemotherapie und Immuntherapie des colorectalen Karzinoms. Übersicht über den heutigen Stand. Tumor Diagn Ther 10:1–12

    Google Scholar 

  28. Shibata J, Fujiyama S, Sato T, Kishimoto S, Fukishima S (1989) Heptaic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma. Cancer 64:1586–1594

    Article  CAS  PubMed  Google Scholar 

  29. Sternlicht M, Daniels JR, Daniels A (1987) Collagen chemoembolisation — pharmacokinetics and tissue tolerance of cisplatin in liver and kidney, Abstracts. 3rd International Conference on Advances in Regional Cancer Therapy. Ulm 1987, p 87

    Google Scholar 

  30. The Liver Cancer Study Group of Japan (1987) Primary liver cancer in Japan. Sixth Report. Cancer 60:1400–1411

    Google Scholar 

  31. Venook AP, Stagg RJ, Lewis BJ, Chase JL, Ring EJ, Maroney P, Hohn DC (1990) Gelfoam chemoembolization for hepatocellular carcinoma. J Clin Oncol

    Google Scholar 

  32. Yumuto Y, Iinno K, Tokuyma K (1985) Hepatocellular carcinoma detected by iodized oil. Radiology 154:19–22

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Allgemeinchirurgie, Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Deutschland

    M. Lorenz, C. Hottenrott, D. Liermann, P. Maier, M. Reimann & J. Kollath

Authors
  1. M. Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Hottenrott
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Liermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Maier
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Reimann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Kollath
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chirurgische Klinik, Ruprecht-Karls-Universität, Im Neuenheimer Feld 110, W-6900, Heidelberg, Deutschland

    Christian Herfarth  & Peter Schlag  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lorenz, M., Hottenrott, C., Liermann, D., Maier, P., Reimann, M., Kollath, J. (1991). Selektive Chemoembolisation von primären und sekundären Lebermalignomen mit Mitomycin C, Lipiodol und Dura. In: Herfarth, C., Schlag, P. (eds) Neue Entwicklungen in der Therapie von Lebertumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76425-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76425-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76426-4

  • Online ISBN: 978-3-642-76425-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation