Proteolysis-Induced Pathomechanisms in Acute Inflammation and Related Therapeutic Approaches

  • M. Jochum
  • W. Machleidt
  • H. Fritz
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 11.–13. April 1991 in Mosbach/Baden book series (MOSBACH, volume 42)

Abstract

Proteolysis-induced pathomechanisms seem to play a major role in the primary response of the organism to inflammatory stimuli such as tissue destruction due to multiple trauma and major surgery or invasive microbes and endotoxins in sepsis. Physiologically, the inflammation response is directed towards inactivating and eliminating the deleterious agents and to initiate the process of repair and healing. Yet, the activation of the complex interacting cellular and humoral defence mechanisms necessary for this purpose carries with it also the risk of damaging healthy tissue, thus perpetuating the inflammatory process. In this respect, the lysosomal serine proteinase elastase and the cysteine proteinase cathepsin B of the primary inflammatory cells, polymorphonuclear (PMN) granulocytes, and monocytes/macrophages are supposed to be potent effectors of proteolytic tissue damage if they are discharged extracellularly in high amounts during activation of the phagocytes. Moreover, proteinases of humoral origin (plasma kallikrein, thrombin, plasmin, complement esterases) and protein split products generated by their proteolytic action (fibrinopeptides and fibrin monomers, fibronectin peptides, complement-derived factors such as C3a, C4a, and C5a, etc.) have been proven to be of major importance as strong stimulators of the primary defence cells.

Keywords

Placebo Glutathione Superoxide Cysteine Heparin 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • M. Jochum
    • 1
  • W. Machleidt
    • 2
  • H. Fritz
    • 1
  1. 1.Department of Clinical Chemistry and Clinical BiochemistrySurgical Clinic City of the University of MunichMunich 2Germany
  2. 2.Institute of Physiological ChemistryPhysical Biochemistry and Cell Biology of the University of MunichMunich 2Germany

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