Probing Myosin Head Structure with Monoclonal Antibodies and Recombinant Technology
Myosins from mammalian striated muscles are hexameric oligomers composed of two heavy chains (MHC) and two pairs of different light chains (LC1 and LC2). Differences in the primary structures of the myosin subunits and various assembly combinations may allow fine modulations of the different myosin properties, such as ATPase activities, affinity for actin, mutual interactions between the light and heavy subunits and MHC associations in thick filaments. These structural variations would thus finally modulate the contractile properties of the corresponding muscles. Physiopathological effectors, like excessive hormone impregnation, mechanical overloading,… could induce dramatic changes in the myosin subunit composition and alter the contractile properties of the affected muscles (Swynghedauw, 1986).
KeywordsHydrolysis Magnesium Oligomer Myopathy Haas
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