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Wirkung von Rökan auf die spezifische Neurotransmitter-Receptorbindung

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Rökan Ginkgo biloba EGb 761

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Zusammenfassung

Männliche Fisher-344-Ratten erhielten während 28 Tagen 100 mg/kg/d Rökan. 24 Stunden nach der letzten Dosis wurden die Tiere durch Decapitation getötet. Anschließend wurden die Hirnregionen mit hoher Konzentration an spezifischen Receptoren entnommen Die Gewebsproben wurden homogenisiert und zentrifugiert. Im Homogenat wurde unmittelbar im Anschluß die Receptorbindung mittels Radioliganden gemessen. Rökan bewirkte eine Zunahme der Muscarin-Receptorpopulation im Hippocampus von Fisher-344-Ratten. Dieses Phänomen war bei älteren Tieren stärker ausgeprägt. Der Wert von Bmax entsprach nach 24monatiger Behandlung mit Verum demjenigen der Kontrollgruppe nach dreimonatiger Versuchsdauer.

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Authors
  1. J. E. Taylor
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Editors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Domagkstraße 12, 4000, Münster, Deutschland

    Fritz H. Kemper

  2. Institut für Physiologie, RWTH, 5100, Aachen, Deutschland

    Holger Schmid-Schönbein

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© 1991 Springer-Verlag · Heidelberg

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Taylor, J.E. (1991). Wirkung von Rökan auf die spezifische Neurotransmitter-Receptorbindung. In: Kemper, F.H., Schmid-Schönbein, H. (eds) Rökan Ginkgo biloba EGb 761. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76407-3_18

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  • DOI: https://doi.org/10.1007/978-3-642-76407-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53648-2

  • Online ISBN: 978-3-642-76407-3

  • eBook Packages: Springer Book Archive

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