Abstract
A protein is a chain molecule which is characterized chemically by the sequence of amino acids (monomers) which form it. At sufficiently high temperature T, the protein exhibits a rather random and loose conformation, and as T is lowered it undergoes a “protein folding transition” [1,2] to one of a few rather tight and specifically ordered conformations. In an organism, a protein occurs in a folded state, the specific nature of which determines its “protein functions”. Perhaps the most important question currently facing microbiologists is the nature and origin of protein folding.
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References
Water Structure at a Water-Polymer Interface, edited by H. H. G. Jellinek (Plenum, New York, 1972).
J. Gao, K. Kuczer, B. Tidor and M. Karplus, Science 244, 1070 (1989), and references therein.
J. L. Vallés and J. W. Halley, J. Chem. Phys. 92, 694 (1990).
J. W. Halley, B. Johnson and J. L. Vallés, (submitted to Phys. Rev. B, 1990).
E. K. Davies, Chemgraf, Chemical Crystallography Laboratory, Chemical Design Ltd., Oxford.
K. Toukan and A. Rahman, Phys. Rev. B31, 2643 (1985).
W. L. Jorgensen and J. Tirado-Rives, J. Am. Chem. Soc. 110, 1657 (1988).
D. W. McCall, D. C. Douglas, L. L. Blyer, G. E. Johnson, L. W. Jielinski, and H. E. Bair, Macromolecules 17, 1644 (1984).
G. H. Fredrikson and E. Helfand, Macromolecules 18, 2201 (1985).
D. Stauffer, Introduction to Percolation Theory, (Taylor and Francis, London and Philadelphia 1985), Chapter 5.
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© 1991 Springer-Verlag Berlin Heidelberg
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Carmesin, HO., Landau, D.P. (1991). A Computer Simulation of Polymers with Gaussian Couplings: Modeling Protein Folding?. In: Landau, D.P., Mon, K.K., Schüttler, HB. (eds) Computer Simulation Studies in Condensed Matter Physics III. Springer Proceedings in Physics, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76382-3_17
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DOI: https://doi.org/10.1007/978-3-642-76382-3_17
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