Baroreceptor Regulation of Capacitance Vessels

  • Roger Hainsworth


Folkow [21] classified blood vessels according to their main function within the circulation. This functional classification corresponds approximately, but not exactly, to the anatomical divisions. Thus, for example, although resistance vessels largely comprise the small precapillary blood vessels across which most of the drop in blood pressure occurs, all blood vessels offer some degree of resistance to blood flow. Similarly, capacitance vessels are usually held to be synonomous with veins but, since all blood vessels throughout the body contain blood, all make some contribution to vascular capacitance.


Carotid Sinus Splanchnic Nerve Capacitance Response Capacitance Vessel Carotid Baroreceptor 
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  1. 1.
    Abboud FM, Eckberg DL, Johannsen UJ, Mark AL (1979) Carotid and cardiopulmonary baroreceptor control of splanchnic and forearm vascular resistance during venous pooling in man. J Physiol (Lond) 286: 173–184Google Scholar
  2. 2.
    Bartelstone HJ (1960) Role of the veins in venous return. Circ Res 8: 1059–1076PubMedGoogle Scholar
  3. 3.
    Bennett TD, MacAnespie CL, Rothe CF (1982) Active hepatic capacitance responses to neural and humoral stimuli in dogs. Am J Physiol 242: H1000–H1009PubMedGoogle Scholar
  4. 4.
    Bevegard BS, Shepherd JT (1966) Circulatory effects of stimulating the carotid arterial receptors in man at rest and during exercise. J Clin Invest 45: 132–142PubMedCrossRefGoogle Scholar
  5. 5.
    Brender D, Webb-Peploe MM (1969) Influence of carotid baroreceptors on different components of the vascular system. J Physiol (Lond) 205: 257–274Google Scholar
  6. 6.
    Brody JS, Stemmler EJ, Dubois AB (1968) Longitudinal distribution of vascular resistance in the pulmonary arteries, capillaries and veins. J Clin Invest 47: 783–799PubMedCrossRefGoogle Scholar
  7. 7.
    Brooksby GA, Donald DE (1972) Release of blood from the splanchnic circulation in dogs. Circ Res 31: 105–118PubMedGoogle Scholar
  8. 8.
    Brunner MN, Shoukas AA, MacAnespie CL (1981) The effect of the carotid sinus baroreceptor reflex on blood flow and volume redistribution in the total systemic vascular bed of the dog. Circ Res 48: 274–285PubMedGoogle Scholar
  9. 9.
    Brunner MJ, Greene AS, Frankle AE, Shoukas A A (1988) Carotid sinus baroreceptor control of splanchnic resistance and capacity. Am J Physiol 255: H1305–1310PubMedGoogle Scholar
  10. 10.
    Burke D, Sundlof G, Wallin BG (1977) Postural effects of muscle nerve sympathetic activity in man. J Physiol (Lond) 272: 399–414Google Scholar
  11. 11.
    Carneiro JJ, Donald DE (1977) Change in liver blood flow and blood content in dogs during direct and reflex alteration of hepatic sympathetic nerve activity. Circ Res 40: 150–158PubMedGoogle Scholar
  12. 12.
    Carneiro JJ, Donald DE (1977) Blood reservoir function of dog spleen, liver, and intestine. Am J Physiol 232: H67–H72PubMedGoogle Scholar
  13. 13.
    Cousineau D, Goresby DA, Rose CP, Lee S (1985) Reflex sympathetic effects on liver vascular space and liver perfusion in dogs. Am J Physiol 248: H186–H192PubMedGoogle Scholar
  14. 14.
    Daly I de B, Daly M de B (1959) The effects of stimulation of the carotid sinus baroreceptors on the pulmonary vascular bed in the dog. J Physiol (Lond) 148: 220–226Google Scholar
  15. 15.
    Di Salvo J, Parker PE, Scott JB, Haddy FJ (1971) Carotid baroreceptor influence on total and segmental resistances in skin and muscle vasculatures. Am J Physiol 220: 1970–1978Google Scholar
  16. 16.
    Dock DS, Kraus WL, McGuire LB, Hyland JW, Haynes FW, Dexter L (1961) The pulmonary blood volume in man. J Clin Invest 40: 317–328PubMedCrossRefGoogle Scholar
  17. 17.
    Donald DE, Aarhus LL (1974) Active and passive release of blood from canine spleen and small intestine. Am J Physiol 227: 1166–1172PubMedGoogle Scholar
  18. 18.
    Eckstein JW, Mark AL, Schmid PG, Iizuka T, Wendling MG (1969) Responses of capacitance vessels to physiologic stimuli. Trans Am Clin Climatol Assoc 81: 57–64Google Scholar
  19. 19.
    Epstein SE, Beiser GD, Stampfer M, Braunwald E (1968) Role of the venous system in baroreceptor-mediated reflexes in man. J Clin Invest 47: 139–152PubMedCrossRefGoogle Scholar
  20. 20.
    Ernsting J, Parry DJ (1957) Some observations on the effects of stimulating the stretch receptors in the carotid artery of man. J Physiol (Lond) 137: 45 PGoogle Scholar
  21. 21.
    Folkow B (1959) The efferent innervation of the carodiovascular system. Verh Dtsch Ges Herz Kreislaufforsch 25: 84–96Google Scholar
  22. 22.
    Ford R, Hainsworth R, Rankin AJ, Soladoye AO (1985) Abdominal vascular responses to changes in carbon dioxide tension in the cephalic circulation of anaesthetized dogs. J Physiol (Lond) 358: 417–431Google Scholar
  23. 23.
    Gauer OH, Thron HL (1965) Postural changes in the circulation. In: Hamilton WF (ed) Circulation. American Physiological Society, Washington, pp 2409–2439 (Handbook of physiology, sect 2, vol 3 )Google Scholar
  24. 24.
    Green HD (1950) Circulatory system: physical principles. In: Glasser O (ed) Medical physics, vol 2. Year Book Medical Publishers, Chicago, p 231Google Scholar
  25. 25.
    Green HD, Rapela CE, Conrad MC (1963) Resistance (conductance) and capacitance phenomena in terminal vascular beds. In: Hamilton WF (ed) Circulation. American Physiological Society, Washington (Handbook of physiology, sect 2, vol 2 )Google Scholar
  26. 26.
    Greene AS, Shoukas A A (1986) Changes in canine cardiac function and venous return curves by the carotid baroreflex. Am J Physiol 251: H288–296PubMedGoogle Scholar
  27. 27.
    Greenway CV, Lautt WW (1988) Distensibility of hepatic venous sites and consequences on portal pressure. Am J Physiol 254: H452–H458PubMedGoogle Scholar
  28. 28.
    Greenway CV, Oshiro G (1972) Comparison of the effects of hepatic nerve stimulation on arterial flow, distribution of arterial and portal flows and blood content in the livers of anaesthetized cats and dogs. J Physiol (Lond) 227: 487–501Google Scholar
  29. 29.
    Greenway CV, Lawson AC, Stark RD (1968) Vascular responses of the spleen to nerve stimulation during normal and reduced blood flow. J Physiol (Lond) 194: 421–433Google Scholar
  30. 30.
    Greenway CV, Stark RD, Lautt WW (1969) Capacitance responses and fluid exchange in the cat liver during stimulation of the hepatic nerves. Circ Res 25: 227–284Google Scholar
  31. 31.
    Guyton AC (1955) Determination of cardiac output by equating venous return curves with cardiac response curves. Physiol Rev 35: 123–129PubMedGoogle Scholar
  32. 32.
    Hadjiminas J, Oberg B (1968) Effects of carotid baroreceptor reflexes on venous tone in skeletal muscle and intestine of the cat. Acta Physiol Scand 72: 518–532PubMedCrossRefGoogle Scholar
  33. 33.
    Hainsworth R (1986) Vascular capacitance: its control and importance. Rev Physiol Biochem Pharmacol 105: 101–173PubMedCrossRefGoogle Scholar
  34. 34.
    Hainsworth R, Al-Shamma YMH (1988) Cardiovascular responses to upright tilting in healthy subjects. Clin Sci 74: 17–22PubMedGoogle Scholar
  35. 35.
    Hainsworth R, Karim F (1976) Responses of abdominal vascular capacitance in the anaesthetized dog to changes in carotid sinus pressure. J Physiol (Lond) 262: 659–677Google Scholar
  36. 36.
    Hainsworth R, Linden RJ (1979) Reflex control of vascular capacitance. In: Guyton AC, Young DB (eds) Cardiovascular physiology III, vol 18. University Park Press, Baltimore, pp 67–124Google Scholar
  37. 37.
    Hainsworth R, Karim F, Stoker JB (1975) The influence of aortic baroreceptors on venous tone in the perfused hind limb of the dog. J Physiol (Lond) 244: 337–251Google Scholar
  38. 38.
    Hainsworth R, Karim F, McGregor KH, Wood LM (1983) Responses of abdominal vascular resistance and capacitance to stimulation of carotid chemoreceptors in anaesthetized dogs. J Physiol (Lond) 334: 409–419Google Scholar
  39. 39.
    Hainsworth R, Karim F, McGregor KH, Wood LM (1983) Hind-limb vascular- capacitance responses in anaesthetized dogs. J Physiol (Lond) 337: 417–428Google Scholar
  40. 40.
    Hainsworth R, McGregor KH, Ford R (1986) Effect of veratridine injected into the aortic root on resistance and capacitance in the abdominal circulation in anaesthetized dogs. Q J Exp Physiol 71: 589–598PubMedGoogle Scholar
  41. 41.
    Hallin RG, Torebjork HE (1974) Single unit sympathetic activity in human skin nerves during rest and various manoeuvres. Acta Physiol Scand 92: 303–317PubMedCrossRefGoogle Scholar
  42. 42.
    Hebert MT, Marshall JM (1988) Direct observations of the effects of baroreceptor stimulation on mesenteric circulation of the rat. J Physiol (Lond) 400: 29–44Google Scholar
  43. 43.
    Hebert MT, Marshall JM (1988) Direct observations of baroreceptor stimulation on skeletal muscle circulation of the rat. J Physiol (Lond) 400: 45–59Google Scholar
  44. 44.
    Hoka S, Bosnjak ZJ, Siker D, Luo R, Kampine JP (1988) Dynamic changes in venous outflow by baroreflex and left ventricular distension. Am J Physiol 254: R212–R221PubMedGoogle Scholar
  45. 45.
    Iizuka T, Mark AL, Wendling MG, Schmid PG, Eckstein JW (1970) Differences in responses of saphenous and mesenteric veins to reflex stimuli. Am J Physiol 219: 1066–1070PubMedGoogle Scholar
  46. 46.
    Karim F, Hainsworth R (1976) Responses of abdominal vascular capacitance to stimulation of splanchnic nerves. Am J Physiol 231: 434–440PubMedGoogle Scholar
  47. 47.
    Karim F, Hainsworth R, Pandey RP (1978) Reflex responses of abdominal vascular capacitance from aortic baroreceptors in dogs. Am J Physiol 235: H488–H493PubMedGoogle Scholar
  48. 48.
    Karim F, Araneda G, Hainsworth R (1980) The influence of perfusate temperature on the responses of a superficial vein in the carotid baroreceptor reflex in dogs. Pflugers Arch 383: 79–85PubMedCrossRefGoogle Scholar
  49. 49.
    Karim F, Hainsworth R, Sofola OA, Wood LM (1980) Responses of the heart to stimulation of aortic body chemoreceptors in dogs. Circ Res 46: 77–83PubMedGoogle Scholar
  50. 50.
    Koizumi K, Brooks CMcC (1972) The integration of autonomic system reactions. Ergeb Physiol 67: 1–68PubMedCrossRefGoogle Scholar
  51. 51.
    Lautt WW, Greenway CV (1972) Hepatic capacitance vessel responses to bilateral carotid occlusion in anaesthetized cats. Can J Physiol Pharmacol 50: 244–247PubMedCrossRefGoogle Scholar
  52. 52.
    Lesh TA, Rothe CF (1969) Sympathetic and hemodynamic effects on capacitance vessels in dog skeletal muscle. Am J Physiol 217: 819–827PubMedGoogle Scholar
  53. 53.
    Mellander S (1960) Comparative studies on the adrenergic neuro-hormonal control of resistance and capacitance blood vessels in the cat. Acta Physiol Scand [Suppl 176] 50: 1–86CrossRefGoogle Scholar
  54. 54.
    Milner WR (1980) Pulmonary circulation. In: Mountcastle VB (ed) Medical physiology, vol 2. Mosby, St Louis, pp 1108–1117Google Scholar
  55. 55.
    Oberg B (1964) Effects of cardiovascular reflexes on net capillary fluid transfer. Acta Physiol Scand [Suppl 229] 62: 1–98Google Scholar
  56. 56.
    Price HL, Deutsch S, Marshall BE, Stephen GW, Behar MG, Neufeld GR (1966) Hemodynamic and metabolic effects of hemorrhage in man, with particular reference to the splanchnic circulation. Circ Res 18: 469–474PubMedGoogle Scholar
  57. 57.
    Rothe CF (1983) Reflex control of veins and vascular capacitance. Physiol Rev 63: 1281–1342PubMedGoogle Scholar
  58. 58.
    Rothe CF (1983) Measurement of circulatory capacitance and resistance. In: Linden RJ (ed) Techniques in cardiovascular physiology. Elsevier, Shannon, pp P306/1–P306/28Google Scholar
  59. 59.
    Rothe CF, Johns BL, Bennett TD (1978) Vascular capacitance of dog intestine using mean transit time of indicator. Am J Physiol 234: H7–H13PubMedGoogle Scholar
  60. 60.
    Rutlen DL, Supple EN, Powell WJ Jr (1981) Beta-adrenergic regulation of total systemic intravascular volume in the dog. Circ Res 48: 112–120PubMedGoogle Scholar
  61. 61.
    Saltzman EW (1957) Reflex peripheral venoconstriction induced by carotid occlusion. Circ Res 5: 149–152Google Scholar
  62. 62.
    Shoukas AA (1975) Pressure-flow and pressure-volume relations in the active pulmonary vascular bed of the dog determined by two-port analysis. Circ Res 37: 809–818PubMedGoogle Scholar
  63. 63.
    Shoukas AA, Sagawa K (1973) Control of total systemic vascular capacity by the carotid sinus baroreceptor reflex. Circ Res 33: 22–23PubMedGoogle Scholar
  64. 64.
    Shoukas AA, MacAnespie CL, Brunner MH, Watermeier L (1981) The importance of the spleen in blood volume shifts of the systemic vascular bed caused by the carotid sinus baroreceptor reflex in the dog. Circ Res 49: 759–766PubMedGoogle Scholar
  65. 65.
    Smyth HS, Sleight P, Pickering GW (1969) Reflex regulation of arterial pressure during sleep in man. Circ Res 24: 109–121PubMedGoogle Scholar
  66. 66.
    Tkachenko BI, Vinogradova MI, Makovskaja VA (1976) Relation of efferent impulse activity in splenic nerve to reflexly induced reactions of resistance and capacitance vessels of spleen. Experientia 32: 1012–1014PubMedCrossRefGoogle Scholar
  67. 67.
    Tutt SM, McGregor KH, Hainsworth R (1988) Reflex vascular responses to changes in left ventricular pressure in anaesthetized dogs. Q J Exp Physiol 73: 425–437PubMedGoogle Scholar
  68. 68.
    Vanhoutte P, Leusen I (1969) The reactivity of isolated venous preparations to electrical stimulation. Pflugers Arch 306: 341–353PubMedCrossRefGoogle Scholar
  69. 69.
    Vukasovic JL, Tutt SM, Crisp AJ, Hainsworth R (1989) The influence of left ventricular pressure on the vascular responses to changes in carotid sinus pressure in anaesthetized dogs. Q J Exp Physiol 74: 735–746PubMedGoogle Scholar
  70. 70.
    Wade OL, Combes B, Childs AW, Wheeler HO, Cownard A, Bradley SE (1956) The effect of exercise on the splanchnic blood flow and splanchnic blood volume in normal man. Clin Sci 15: 451–463Google Scholar
  71. 71.
    Webb-Peploe MM, Shepherd JT (1968) Response of large hindlimb veins of the dog to sympathetic nerve stimulation. Am J Physiol 215: 299–307PubMedGoogle Scholar
  72. 72.
    Webb-Peploe MM, Shepherd JT (1968) Responses of the superficial limb veins of the dog to changes in temperature. Circ Res 22: 737–746Google Scholar
  73. 73.
    Zingher D, Grodins S (1964) Effect of carotid baroreceptor stimulation upon the forelimb vascular bed of the dog. Circ Res 14: 392–399PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Roger Hainsworth
    • 1
  1. 1.Department of Cardiovascular StudiesThe University of LeedsLeedsUK

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