Abstract
During the 1960s at Rotta Research Laboratorium, Rovati [1] developed a gastrin receptor antagonist named proglumide, i.e., DL-4-benzamido-N, N-dipropyl-glutaramic acid. Proglumide has been used for several years for the treatment of peptic ulcer.
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References
Rovati AL (1968) The relationship between chemical structure of a new dicarboxylic amino-acid derivative and antigastrin activity in the rat. Br J Pharmacol 34:677–682
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© 1991 Springer-Verlag Berlin Heidelberg
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Rovati, L.C. (1991). Pentanoic Acid Derivatives. In: Adler, G., Beglinger, C. (eds) Cholecystokinin Antagonists in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76362-5_7
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DOI: https://doi.org/10.1007/978-3-642-76362-5_7
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