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Biological Actions of CCK in the Gastrointestinal Tract

  • Chapter
Cholecystokinin Antagonists in Gastroenterology

Abstract

CCK was first described over 60 years ago as a putative hormone that caused gallbladder contraction in response to fat in the intestine [1]. Thirty-five years later, it was shown that CCK was chemically identical with pancreozymin [2], another putative hormone thought to cause pancreatic enzyme secretion in response to fat and protein in the intestine [3]. In the years since the discoveries of these two major actions, CCK has been found to have many additional effects in the gastrointestinal tract and other organ systems. Early progress consisted mainly of describing the effects of increasingly pure preparations of CCK (including synthetic forms) and determining responses of many target organs. These approaches provided a wealth of data on the potential effects of CCK and continue to do so today, but they do not define which of these many responses of the gastrointestinal tract to exogenous stimulation are in fact regulated by endogenous CCK. Table 1 summarizes many of the reported actions of exogenous CCK.

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Author information

Authors and Affiliations

  1. Kansas City, VA Medical Center, 4801 Linwood Blvd., Kansas City, MO, 64068, USA

    T. E. Solomon

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  1. T. E. Solomon
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Editors and Affiliations

  1. Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik Oberer Eselsberg, Robert-Koch-Straße 8, W-7900, Ulm, Germany

    Guido Adler

  2. Abteilung für Gastroenterologie, Universitätsklinik, Petersgraben 6, 4031, Basel, Switzerland

    Christoph Beglinger

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© 1991 Springer-Verlag Berlin Heidelberg

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Solomon, T.E. (1991). Biological Actions of CCK in the Gastrointestinal Tract. In: Adler, G., Beglinger, C. (eds) Cholecystokinin Antagonists in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76362-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-76362-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76364-9

  • Online ISBN: 978-3-642-76362-5

  • eBook Packages: Springer Book Archive

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