The Role of CCK in Tumor Growth

  • T. E. Solomon

Abstract

Cancers of the gastrointestinal tract, particularly those of colonic, pancreatic, and gastric origin, are major causes of disability and death in the Western world. There has been little progress in our understanding of the causes and progression of these diseases in spite of remarkable advances in the area of tumor biology. One such advance is the realization that “growth factors” may modulate the proliferative rates of malignant neoplasms. Peptides such as epidermal growth factor, the transforming growth factors, and several others may affect tumor growth through direct actions on tumor cell receptors, receptors may be “overexpressed” in tumor cells, and these factors may even be synthesized and released by tumor cells to initiate autocrine growth stimulation. It is also possible that other substances, such as gastrointestinal hormones, may modulate cancer cell growth rates. This idea comes from the well-known trophic effects of gastrointestinal peptide hormones on various target tissues, and the possibility that malignant cells originating from these tissues may retain specific hormonal receptors that still influence proliferation. CCK is a potent growth stimulant of the normal exocrine pancreas [1], and many studies have used this background as an impetus to determine whether CCK also affects pancreatic cancer growth. Several reviews are available on the topic of gastrointestinal hormones and their potential role in pancreatic and other gastrointestinal cancers [2–6]

Keywords

Adenocarcinoma Oncol Gelatin Thymidine Secretin 

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References

  1. 1.
    Solomon TE, Petersen H, Elashoff J, Grossman MI (1978) Interaction of caerulein and secretin on pancreatic size and composition in rat. Am J Physiol 235:E714–E719PubMedGoogle Scholar
  2. 2.
    Townsend CM Jr, Singh P, Thompson JC (1986) Gastrointestinal hormones and gastrointestinal and pancreatic carcinomas. Gastroenterology 91:1002–1006PubMedGoogle Scholar
  3. 3.
    Longnecker DS (1987) Interface between adaptive and neoplastic growth in the pancreas. Gut 28 (Sl):253–258PubMedCrossRefGoogle Scholar
  4. 4.
    Longnecker DS, Jamieson JD, Asch HL (1989) Conference report. Regulation of growth and differentiation in pancreatic cancer. Pancreas 4:256–275CrossRefGoogle Scholar
  5. 5.
    Townsend CM Jr, Singh P, Thompson JC (1989) Effects of gastrointestinal peptides on gastrointestinal cancer growth. Gastroenterol Clin North Am 18: 777–791PubMedGoogle Scholar
  6. 6.
    Andren-Sandberg A (1989) Peptide hormone influence on exocrine pancreatic cancer. Eur J Surg Oncol 15:236–241PubMedGoogle Scholar
  7. 7.
    Beazley RM, Cohn I Jr (1988) Update on pancreatic cancer. CA 38:310–319PubMedGoogle Scholar
  8. 8.
    Wormsley KG (1985) Aetiology of pancreatic cancer. Ital J Gastroenterol 17: 102–108Google Scholar
  9. 9.
    Hudd C, LaRegina MC, Devine JE, Palmer DC, Herbold DR, Beinfeld MC, Gelder FB, Johnson FE (1989) Response to exogenous cholecystokinin of six human gastrointestinal cancers xenografted in nude mice. Am J Surg 157: 386–394PubMedCrossRefGoogle Scholar
  10. 10.
    Smith JP, Solomon TE, Bagheri S, Kramer S (1990) Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990. Dig Dis Sci 35: 1377–1384PubMedCrossRefGoogle Scholar
  11. 11.
    Smith JP, Kramer S, Bagheri S (1990) Effects of a high-fat diet and L-364718 on growth of human pancreas cancer. Dig Dis Sci 35:726–732PubMedCrossRefGoogle Scholar
  12. 12.
    Alexander RW, Upp JR, Poston GJ, Townsend CM Jr, Singh P, Thompson JC (1988) Bombesin inhibits growth of human pancreatic adenocarcinoma in nude mice. Pancreas 3:297–302PubMedCrossRefGoogle Scholar
  13. 13.
    Smith JP, Kramer ST, Solomon TE (1991) CCK stimulates growth of six human pancreatic cancer cell lines in serum-free medium. Regul Pept (in press)Google Scholar
  14. 14.
    Liehr R-M, Melnykovych G, Solomon TE (1990) Growth effects of regulatory peptides on human pancreatic cancer lines PANC-1 and MIA PaCa-2. Gastroenterology 98:1666–1674PubMedGoogle Scholar
  15. 15.
    Frazier ML, Pathak S, Wang Z-W, Cleary K, Singletary SE, Olive M, MacKay B, Steck PA, Levin B (1990) Establishment of a new human pancreatic adenocarinoma cell line, MDAPanc-3. Pancreas 5:8–16PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • T. E. Solomon
    • 1
  1. 1.Kansas CityVA Medical CenterKansas CityUSA

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