Effects of CCK Antagonists on Intestinal Motility in Dogs

  • M. Karaus
  • C. Niederau

Abstract

The motility of the canine small and large intestine consists of cyclic motor patterns which are controlled by neural and hormonal factors. During the interdigestive state, a specific motor pattern called the migrating motor complex (MMC) occurs rhythmically in the small intestine. The MMC cycle is characterized by four phases: Phase one has little or no activity, phase two has intermittent and irregular contractions, during phase three the bowel contracts at its maximum frequency, and phase four is the following transition period back to quiescence. Phase three of the MMC is migrating aborally along the bowel. A meal sharply interrupts the MMC cycle and causes a prolonged increase in irregular contractile activity similar to phase two activity [2,14,22]. The canine colon also shows a cyclic motor pattern called the colonic motor complex (CMC), consisting of rhythmic bursts of tonic and phasic contractions [16]. After a meal the cyclic motor pattern of the colon is not interrupted but the motor activity is increased in the distal half of the colon. This is called the gastrocolonic response [15].

Keywords

Serotonin Polypeptide Histamine Luminal Acetylcholine 

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References

  1. 1.
    Barone FS, Ormsbee HS, White RF, Labosh TJ (1984) The effects of cholecystokinin and cholecystokinin receptor antagonists on proximal colonic motility of the anaesthetized dog. Dig Dis Sci [Suppl] 29:8SGoogle Scholar
  2. 2.
    Code CF, Marlett JA (1975) Then interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (Lond) 246:289–309Google Scholar
  3. 3.
    Dinoso VP, Meshkinpur H, Lorber SH, Guitierrez JG, Chey WY (1973) Motor responses of the sigmoid colon and rectum to exogenous cholecystokinin and secretin. Gastroenterology 45:364–367Google Scholar
  4. 4.
    Egberts EH, Johnson AG (1977) The effect of cholecystokinin on human taenia coli. Digestion 15:217–222PubMedCrossRefGoogle Scholar
  5. 5.
    Harvey RF, Read AE (1973) Effect of cholecystokinin on colonic motility and symptoms in patients with the irritable-bowel syndrome. Lancet 1:1–3PubMedCrossRefGoogle Scholar
  6. 6.
    Karaus M, Niederau C (1989) Effects of CCK-receptor antagonist on colonic motility in the dog. Gastroenterology 96:A248Google Scholar
  7. 7.
    Kerlin P, Phillips SF (1982) Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology 82:694–700PubMedGoogle Scholar
  8. 8.
    Liberge M, Bueno L (1989) CCK-8 neurons of the ventromedial hypothalamus (VMH) mediated the upper gut motor changes associated with feeding in rats. J Gastrointest Motil 1:54AGoogle Scholar
  9. 9.
    Merlo A, Cohen S (1988) Neuropeptide responses and mechanics of the proximal and distal feline colon in vitro. Am J Physiol 255:G787–G793PubMedGoogle Scholar
  10. 10.
    Mukopadhyay AK, Thor PF, Copeland EM, Johnson LR, Weisbrodt NW (1977) Effect of cholecystokinin on myoelectrical activity of small bowel in the dog. Am J Physiol 232:E44–E47Google Scholar
  11. 11.
    Niederau C, Karaus M (1989) Effects of CCK-receptor blockade on fed and fasted small intestinal motor activity. Gastroenterology 96:A366Google Scholar
  12. 12.
    Niederau C, Karaus M (1990) Effects of agonists and antagonists of cholecystokinin on contractile and myoelectrical activity of colonic and ileal muscle in the dog and guinea pig in vitro. J Gastrointest Motil 2(3): 169–175Google Scholar
  13. 13.
    Niederau C, Heindges T, Rovati L, Strohmeyer G (1989) Effects of loxiglumide on gallbladder emptying in healthy volunteers. Gastroenterology 97:1331–1336PubMedGoogle Scholar
  14. 14.
    Sarna SK (1985) Cyclic motor activity; migrating motor complex. Gastroenterology 89:894–913PubMedGoogle Scholar
  15. 15.
    Sarna SK, Lang IM (1989) Colonic motor response to a meal in dogs. Am J Physiol 257:G830–G835PubMedGoogle Scholar
  16. 16.
    Sarna SK, Condon R, Cowles V (1984) Colonic migrating and nonmigrating motor complexes in dogs. Am J Physiol 246:G355–G360PubMedGoogle Scholar
  17. 17.
    Schang JC, Kelly KA (1981) Inhibition of canine interdigestive proximal gastric motility by cholecystokinin octapeptide. Am J Physiol 240:G217–G220PubMedGoogle Scholar
  18. 18.
    Schemann M, Siegle ML, Sayhoun H, Ehrlein HJ (1986) Computer analysis of intestinal motility: effects of cholecystokinin and neurotensin on jejunal contraction patterns. Z Gastroenterol 24:262–268PubMedGoogle Scholar
  19. 19.
    Schumann MA, Kreulen DL (1986) Action of cholecystokinin octapeptide and CCK-related peptides on neurons in inferior mesenteric ganglion of guinea pigs. J Pharmacol Exp Ther 239:618–625PubMedGoogle Scholar
  20. 20.
    Snape WJ (1983) Interaction of the octapeptide of cholecystokinin and gastrin I with bethanecol in the stimulation of feline colonic smooth muscle. Gastroenterology 84:58–62PubMedGoogle Scholar
  21. 21.
    Steward JJ, Burks TF (1977) Actions of cholecystokinin octapeptide on smooth muscle of isolated dog intestine. Am J Physiol 232:E306–E310Google Scholar
  22. 22.
    Szurszewski JH (1969) A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763PubMedGoogle Scholar
  23. 23.
    Thor P, Laskiewicz J, Konturek P, Konturek SJ (1988) Cholecystokinin in the requlation of intestinal motility and pancreatic secretion in dogs. Am J Physiol 255:G498–G504PubMedGoogle Scholar
  24. 24.
    Thor P, Konturek SJ, Laskiewicz J, Maczka M (1990) Role of cholecystokinin in gallbladder and duodenal motility in the interdigestive state of dogs. J Gastrointest Motil 2(l):40–46Google Scholar
  25. 25.
    Vizi SE, Bertacini G, Impicciatore M, Knoll J (1973) Evidence that acetylcholine released by gastrin and related polypeptides contributes to their effect on gastrointestinal motility. Gastroenterology 64:268–277PubMedGoogle Scholar
  26. 26.
    Weisbrodt NM (1987) Motility of the small intestine. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 631–663Google Scholar
  27. 27.
    Wiley J, Owyang C (1987) Participation of serotonin and substance P in the action of cholecystokinin on colonic motility. Am J Physiol 252:G431–G435PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • M. Karaus
    • 1
  • C. Niederau
    • 2
  1. 1.Universitätsklinikum Rudolf Virchow, Standort CharlottenburgFreie Universität BerlinBerlin 19Germany
  2. 2.Department of Internal Medicine, Div. of GastroenterologyHeinrich-Heine-University of DüsseldorfDüsseldorfGermany

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