Abstract
Thyroid epithelial cells, like almost all cells except red blood cells, express surface antigens coded for by the class I genes of the major histocompatibility complex (MHC). These antigens are recognized by syngeneic T cells expressing CD 8 antigen. The T cell receptor of the thyroid-specific CD 8+ T cell combines with the MHC class I antigen, which encloses a thyroid-specific antigen within a well-defined cleft, to initiate cytolysis of the thyroid epithelial cell [1]. This phenomenon has been demonstrated in murine and rat models of experimental autoimmune thyroiditis as well as in human autoimmune thyroiditis [2,3]. In such a situation the thyroid epithelial cell acts as an antigen-presenting cell, and such presentation is prevented by antibodies to MHC class I antigens (MHC restriction).
Supported in part by grants DK28242 and DK35674 from the NIDDKD.
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References
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© 1991 Springer-Verlag Berlin Heidelberg
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Davies, T.F., Neufeld, D. (1991). The Genetic Control of Thyroid Cell MHC Class II Antigen Expression. In: Scherbaum, W.A., Bogner, U., Weinheimer, B., Bottazzo, G.F. (eds) Autoimmune Thyroiditis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76301-4_7
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DOI: https://doi.org/10.1007/978-3-642-76301-4_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53476-1
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